Sca1-Derived Cells Are a Source of Myocardial Renewal in the Murine Adult Heart

被引：113

作者：

Uchida, Shizuka ^{[1
,2
]}

De Gaspari, Piera ^{[1
]}

Kostin, Sawa ^{[1
]}

Jenniches, Katharina ^{[1
]}

Kilic, Ayse ^{[3
]}

Izumiya, Yasuhiro ^{[4
]}

Shiojima, Ichiro ^{[5
]}

Kreymborg, Karsten Grosse ^{[1
]}

Renz, Harald ^{[3
]}

Walsh, Kenneth ^{[6
]}

Braun, Thomas ^{[1
]}

机构：

[1] Max Planck Inst Heart & Lung Res, D-61231 Bad Nauheim, Germany

[2] Goethe Univ Frankfurt, Ctr Mol Med, Inst Cardiovasc Regenerat, D-60590 Frankfurt, Germany

[3] Univ Marburg, Inst Lab Med & Pathobiochem, D-35043 Marburg, Germany

[4] Kumamoto Univ, Grad Sch Med Sci, Dept Cardiovasc Med, Kumamoto 8608556, Japan

[5] Kansai Med Univ, Dept Med 2, Osaka 5731010, Japan

[6] Boston Univ, Whitaker Cardiovasc Inst, Boston, MA 02118 USA

来源：

STEM CELL REPORTS | 2013年 / 1卷 / 05期

关键词：

CARDIAC PROGENITOR CELLS; HEMATOPOIETIC STEM-CELLS; SKELETAL-MUSCLE; CARDIOMYOCYTE RENEWAL; ENDOTHELIAL-CELLS; MOUSE HEART; IN-VIVO; REGENERATION; EXPRESSION; DIFFERENTIATION;

D O I：

10.1016/j.stemcr.2013.09.004

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Although the mammalian heart is one of the least regenerative organs in the body, recent evidence indicates that the myocardium undergoes a certain degree of renewal to maintain homeostasis during normal aging. However, the cellular origin of cardiomyocyte renewal has remained elusive due to lack of lineage tracing experiments focusing on putative adult cardiac precursor cells. We have generated triple-transgenic mice based on the tet-cre system to identify descendants of cells that have expressed the stem cell marker Sca1. We found a significant and lasting contribution of Sca1-derived cells to cardiomyocytes during normal aging. Ischemic damage and pressure overload resulted in increased differentiation of Sca1-derived cells to the different cell types present in the heart. Our results reveal a source of cells for cardiomyocyte renewal and provide a possible explanation for the limited contribution of Sca1-derived cells to myocardial repair under pathological conditions.

引用

页码：397 / 410

页数：14

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