Nickel-Catalyzed Reductive Methylation of Alkyl Halides and Acid Chlorides with Methyl p-Tosylate

被引：90

作者：

Liang, Zhuye ^{[1
]}

Xue, Weichao ^{[2
]}

Lin, Kunhua ^{[2
]}

Gong, Hegui ^{[2
]}

机构：

[1] Zhengzhou Univ, Coll Chem & Mol Engn, Zhengzhou 450001, Peoples R China

[2] Shanghai Univ, Dept Chem, Shanghai 200444, Peoples R China

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 21期

关键词：

CROSS-COUPLING REACTIONS; ARYL HALIDES; ALKYLBORONIC ESTERS; GRIGNARD-REAGENTS; KETONE FORMATION; NI; BORYLATION; BROMIDES; BOND; CARBOXYLATION;

D O I：

10.1021/ol502682q

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Methylation of unactivated alkyl halides and acid chlorides under Ni-catalyzed reductive coupling conditions led to efficient formation of methylated alkanes and ketones using methyl p-methyl tosylate as the methylation reagent. Moderate to excellent coupling yields as well as excellent functional group tolerance were observed under the present mild and easy-to-operate reaction conditions.

引用

页码：5620 / 5623

页数：4

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