Mitochondrial toxicity assessment in industry - a decade of technology development and insight

被引：93
作者：
Will, Yvonne [1 ]
Dykens, James [2 ]
机构：
[1] Pfizer Global Research & Dev, Compound Safety Predict WWMC, Groton, CT 06340 USA
[2] Eyecyte Therapeut, San Diego, CA USA
来源：
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY | 2014年 / 10卷 / 08期
关键词：
drugs; liver injury; mitochondria; toxicity; LIVER-INJURY; HEPG2; CELLS; IN-VITRO; DYSFUNCTION; NECROSIS; ASSAY; CYTOTOXICITY; TROGLITAZONE; RESPIRATION; DNA;
D O I：
10.1517/17425255.2014.939628
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
[No abstract available]
引用
收藏
页码：1061 / 1067
页数：7
相关论文
共 32 条
[1]  
Aleo MD, 2014, HEPATOLOGY
[2]   Mitochondrial function in vivo: Spectroscopy provides window on cellular energetics [J].
Amara, Catherine E. ;
Marcinek, David J. ;
Shankland, Eric G. ;
Schenkman, Kenneth A. ;
Arakaki, Lorilee S. L. ;
Conley, Kevin E. .
METHODS, 2008, 46 (04) :312-318
[3]   Mitochondrial DNA and disease [J].
Dimauro, S ;
Davidzon, G .
ANNALS OF MEDICINE, 2005, 37 (03) :222-232
[4]   In vitro assessment of mitochondrial dysfunction and cytotoxicity of nefazodone, trazodone, and buspirone [J].
Dykens, James A. ;
Jamieson, Joseph D. ;
Marroquin, Lisa D. ;
Nadanaciva, Sashi ;
Xu, Jinghai J. ;
Dunn, Margaret C. ;
Smith, Arthur R. ;
Will, Yvonne .
TOXICOLOGICAL SCIENCES, 2008, 103 (02) :335-345
[5]   Strategies to reduce late-stage drug attrition due to mitochondrial toxicity [J].
Dykens, James A. ;
Marroquin, Lisa D. ;
Will, Yvonne .
EXPERT REVIEW OF MOLECULAR DIAGNOSTICS, 2007, 7 (02) :161-175
[6]   Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro [J].
Dykens, James A. ;
Jamieson, Joseph ;
Marroquin, Lisa ;
Nadanaciva, Sashi ;
Billis, Puja A. ;
Will, Yvonne .
TOXICOLOGY AND APPLIED PHARMACOLOGY, 2008, 233 (02) :203-210
[7]   The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation [J].
Halestrap, AP ;
Price, NT .
BIOCHEMICAL JOURNAL, 1999, 343 :281-299
[8]   Trovafloxacin, a fluoroquinolone antibiotic with hepatotoxic potential, causes mitochondrial peroxynitrite stress in a mouse model of underlying mitochondrial dysfunction [J].
Hsiao, Chin-Ju J. ;
Younis, Husam ;
Boelsterli, Urs A. .
CHEMICO-BIOLOGICAL INTERACTIONS, 2010, 188 (01) :204-213
[9]   Investigation of drug-induced mitochondrial toxicity using fluorescence-based oxygen-sensitive probes [J].
Hynes, James ;
Marroquin, Lisa D. ;
Ogurtsov, Vladimir I. ;
Christiansen, Katerina N. ;
Stevens, Gregory J. ;
Papkovsky, Dmitri B. ;
Will, Yvonne .
TOXICOLOGICAL SCIENCES, 2006, 92 (01) :186-200
[10]   A high-throughput dual parameter assay for assessing drug-induced mitochondrial dysfunction provides additional predictivity over two established mitochondrial toxicity assays [J].
Hynes, James ;
Nadanaciva, Sashi ;
Swiss, Rachel ;
Carey, Conn ;
Kirwan, Sinead ;
Will, Yvonne .
TOXICOLOGY IN VITRO, 2013, 27 (02) :560-569
1234