Meta-analysis of loci associated with age at natural menopause in African-American women

被引：50

作者：

Chen, Christina T. L. ^{[1
]}

Liu, Ching-Ti ^{[2
,3
]}

Chen, Gary K. ^{[4
]}

Andrews, Jeanette S. ^{[7
]}

Arnold, Alice M. ^{[8
]}

Dreyfus, Jill ^{[9
]}

Franceschini, Nora ^{[10
]}

Garcia, Melissa E. ^{[13
]}

Kerr, Kathleen F. ^{[8
]}

Li, Guo ^{[8
]}

Lohman, Kurt K. ^{[7
]}

Musani, Solomon K. ^{[14
]}

Nalls, Michael A. ^{[16
]}

Raffel, Leslie J. ^{[17
]}

Smith, Jennifer ^{[19
]}

Ambrosone, Christine B. ^{[20
]}

Bandera, Elisa V. ^{[21
]}

Bernstein, Leslie ^{[22
]}

Britton, Angela ^{[16
]}

Brzyski, Robert G. ^{[23
]}

Cappola, Anne ^{[24
]}

Carlson, Christopher S. ^{[1
]}

Couper, David ^{[11
]}

Deming, Sandra L. ^{[25
]}

Goodarzi, Mark O. ^{[18
]}

Heiss, Gerardo ^{[10
]}

John, Esther M. ^{[26
]}

Lu, Xiaoning ^{[2
,27
]}

Le Marchand, Loic ^{[28
]}

Marciante, Kristin ^{[8
]}

Mcknight, Barbara ^{[8
]}

Millikan, Robert ^{[10
,12
]}

Nock, Nora L. ^{[29
]}

Olshan, Andrew F. ^{[10
,12
]}

Press, Michael F. ^{[5
,6
]}

Vaiyda, Dhananjay ^{[30
]}

Woods, Nancy F. ^{[31
]}

Taylor, Herman A. ^{[14
]}

Zhao, Wei ^{[19
]}

Zheng, Wei ^{[25
]}

Evans, Michele K. ^{[32
]}

Harris, Tamara B. ^{[13
]}

Henderson, Brian E. ^{[4
]}

Kardia, Sharon L. R. ^{[19
]}

Kooperberg, Charles ^{[1
]}

Liu, Yongmei ^{[34
]}

Mosley, Thomas H. ^{[15
]}

Psaty, Bruce ^{[35
,36
,37
]}

Wellons, Melissa ^{[38
]}

Windham, Beverly G. ^{[15
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, Seattle, WA 98109 USA

[2] Boston Univ, Dept Biostat, Sch Publ Hlth, Boston, MA 02118 USA

[3] NHLBI, Framingham Heart Study, Framingham, MA 01702 USA

[4] Univ So Calif, Dept Prevent Med, Los Angeles, CA 90089 USA

[5] Univ So Calif, Dept Pathol, Keck Sch Med, Los Angeles, CA 90089 USA

[6] Univ So Calif, Norris Comprehens Canc Ctr, Los Angeles, CA 90089 USA

[7] Wake Forest Sch Med, Div Publ Hlth Sci, Dept Biostat Sci, Winston Salem, NC 27157 USA

[8] Wake Forest Sch Med, Dept Med, Winston Salem, NC 27157 USA

[9] Univ Minnesota, Div Epidemiol & Community Hlth, Sch Publ Hlth, Minneapolis, MN 55455 USA

[10] Univ N Carolina, Dept Epidemiol, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27514 USA

[11] Univ N Carolina, Dept Biostat, Gillings Sch Global Publ Hlth, Chapel Hill, NC 27514 USA

[12] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27514 USA

[13] NIA, Lab Epidemiol & Populat Sci, Bethesda, MD 20814 USA

[14] Univ Mississippi, Med Ctr, Jackson, MS 39216 USA

[15] Univ Mississippi, Med Ctr, Div Geriatr Med, Jackson, MS 39216 USA

[16] NIA, Neurogenet Lab, NIH, Bethesda, MD 20892 USA

[17] Cedars Sinai Med Ctr, Dept Pediat & Biomed Sci, Los Angeles, CA 90048 USA

[18] Cedars Sinai Med Ctr, Div Endocrinol Diabet & Metab, Los Angeles, CA 90048 USA

[19] Univ Michigan, Dept Epidemiol, Ann Arbor, MI 48109 USA

[20] Roswell Pk Canc Inst, Dept Canc Prevent & Control, Buffalo, NY 14263 USA

[21] Canc Inst New Jersey, New Brunswick, NJ 08903 USA

[22] City Hope Natl Med Ctr, Beckman Res Inst, Dept Populat Sci, Div Canc Etiol, Duarte, CA 91010 USA

[23] Univ Texas Hlth Sci Ctr San Antonio, Dept Obstet & Gynecol, San Antonio, TX 78229 USA

[24] Univ Penn, Perelman Sch Med, Div Endocrinol Diabet & Metab, Philadelphia, PA 19104 USA

[25] Vanderbilt Univ, Sch Med, Dept Med, Div Epidemiol, Nashville, TN 37232 USA

[26] Stanford Univ, Sch Med, Dept Hlth Res & Policy, Div Epidemiol, Stanford, CA 94305 USA

[27] Beth Israel Deaconess Med Ctr, Div Clin Informat, Boston, MA 02118 USA

[28] Univ Hawaii, Program Epidemiol, Canc Res Ctr, Honolulu, HI 96813 USA

[29] Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA

[30] Johns Hopkins Univ, Dept Med, Baltimore, MD 21287 USA

[31] Univ Washington, Seattle, WA 98109 USA

[32] NIA, Hlth Dispar Res Sect, Clin Res Branch, NIH, Baltimore, MD 21224 USA

[33] NIA, Lab Personal & Cognit, NIH, Baltimore, MD 21224 USA

[34] Wake Forest Univ, Dept Epidemiol & Prevent, Div Publ Hlth Sci, Sch Med, Winston Salem, NC 27157 USA

[35] Univ Washington, Dept Med, Seattle, WA USA

[36] Univ Washington, Dept Epidemiol, Seattle, WA 98195 USA

[37] Univ Washington, Dept Hlth Serv, Seattle, WA 98195 USA

[38] Vanderbilt Univ, Sch Med, Nashville, TN 37240 USA

[39] Boston Univ, Sch Med, Dept Med, Sect Gen Internal Med, Boston, MA 02118 USA

[40] Univ Pittsburgh, Dept Obstet Gynecol & Reprod Sci, Pittsburgh, PA 15213 USA

来源：

HUMAN MOLECULAR GENETICS | 2014年 / 23卷 / 12期

基金：

美国国家卫生研究院;

关键词：

GENOME-WIDE ASSOCIATION; PREMATURE OVARIAN FAILURE; MULTILOCUS GENOTYPE DATA; RECEPTOR GENE; INFERENCE; POLYMORPHISMS; MENARCHE; ONSET; RISK; EPIDEMIOLOGY;

D O I：

10.1093/hmg/ddu041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Age at menopause marks the end of a woman's reproductive life and its timing associates with risks for cancer, cardiovascular and bone disorders. GWAS and candidate gene studies conducted in women of European ancestry have identified 27 loci associated with age at menopause. The relevance of these loci to women of African ancestry has not been previously studied. We therefore sought to uncover additional menopause loci and investigate the relevance of European menopause loci by performing a GWAS meta-analysis in 6510 women with African ancestry derived from 11 studies across the USA. We did not identify any additional loci significantly associated with age at menopause in African Americans. We replicated the associations between six loci and age at menopause (P-value < 0.05): AMHR2, RHBLD2, PRIM1, HK3/UMC1, BRSK1/TMEM150B and MCM8. In addition, associations of 14 loci are directionally consistent with previous reports. We provide evidence that genetic variants influencing reproductive traits identified in European populations are also important in women of African ancestry residing in USA.

引用

页码：3327 / 3342

页数：16

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