Severe toxic rhabdomyolysis under combined palbociclib and simvastatin treatment: A case report

被引：0

作者：

Francois, Poumeaud ^{[1
]}

Anna, Fontanier ^{[2
]}

Jeremie, Dion ^{[3
]}

Quentin, Mathevet ^{[2
]}

Olivier, Cointault ^{[4
]}

Emmanuelle, Uro-Coste ^{[5
]}

Celine, Marty ^{[2
]}

Florence, Dalenc ^{[1
]}

Pierre, Girardie ^{[6
]}

Anais, Rataboul ^{[1
]}

机构：

[1] Inst Univ Canc Toulouse Oncopole, Dept Med Oncol, Inst Claudius Regaud, Toulouse, France

[2] Inst Univ Canc Toulouse Oncopole, Dept Clin Pharm, Inst Claudius Regaud, Toulouse, France

[3] Univ Toulouse, Dept Internal Med & Clin Immunol, Ctr Hosp, Toulouse, France

[4] Univ Toulouse, Dept Nephrol, Ctr Hosp, Toulouse, France

[5] Inst Univ Canc Toulouse Oncopole, Dept Anatomo Pathol, Toulouse, France

[6] Univ Toulouse Purpan, Dept Neurol, Ctr Hosp, Toulouse, France

来源：

FRONTIERS IN ONCOLOGY | 2022年 / 12卷

关键词：

rhabdomyolysis; palbociclib; simvastatin; interaction; myositis; plasmatic exchange; 4/6 INHIBITOR PALBOCICLIB; BREAST-CANCER; EZETIMIBE; FULVESTRANT; COMBINATION; THERAPY;

D O I：

10.3389/fonc.2022.1026434

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report the fourth described case of severe toxic rhabdomyolysis occurring in an 81-year-old woman caused by the concomitant administration of palbociclib taken at the usual dosage (125 mg per day) and simvastatin. To the best of our knowledge, this is the first reported case successfully treated by plasma exchanges, with complete functional recovery within two months. The severity of this case justifies further consideration of pharmacokinetic interactions between palbociclib or other CDK-4-6 inhibitors and statins, which potentially increase the risk of an adverse event.

引用

页数：6

共 50 条

[31] Simvastatin interactionInteraction with concomitant cyclosporin, gemfibrozil and itraconazole leading to rhabdomyolysis: case report
Reactions Weekly, 2002, 909 (1) : 15 - 15
[32] Ciclosporin interactionInteraction with concomitant simvastatin leading to rhabdomyolysis in an elderly patient: case report
Reactions Weekly, 2007, 1177 (1) : 9 - 9
[33] Rhabdomyolysis and severe hypercalcemia. Report of one case
Huidobro E, Juan Pablo
Santander, Jaime
Vicentini, Daniel
Jara, Aquiles
REVISTA MEDICA DE CHILE, 2019, 147 (01) : 125 - 129
[34] Simvastatin interactionInteraction with concomitant ciclosporin leading to rhabdomyolysis in an elderly patient: case report
Reactions Weekly, 2006, 1123 (1) : 19 - 19
[35] Simvastatin interactionInteraction with concomitant ciclosporin leading rhabdomyolysis in an elderly patient: case report
Reactions Weekly, 2007, 1133 (1) : 23 - 23
[36] Simvastatin interactionInteraction with concomitant fenofibrate leading to rhabdomyolysis in an elderly patient: case report
Reactions Weekly, 2005, 1057 (1) : 18 - 18
[37] Simvastatin interactionInteraction with concomitant ketoconazole leading to rhabdomyolysis in an elderly patient: case report
Reactions Weekly, 2003, 964 (1) : 14 - 14
[38] Rhabdomyolysis induced by rosuvastatin combined with entecavir: a case report
Wang, Wen
Lu, Xu
Li, Chengbo
Teng, Wei
Cui, Wei
BMC INFECTIOUS DISEASES, 2022, 22 (01)
[39] Rhabdomyolysis induced by rosuvastatin combined with entecavir: a case report
Wen Wang
Xu Lu
Chengbo Li
Wei Teng
Wei Cui
BMC Infectious Diseases, 22
[40] Simvastatin interactionFirst report of an interaction with concomitant amoxicillin leading to rhabdomyolysis in an elderly patient: case report
Reactions Weekly, 2005, 1033 (1) : 10 - 11

← 1 2 3 4 5 →