Severe toxic rhabdomyolysis under combined palbociclib and simvastatin treatment: A case report

被引：0

作者：

Francois, Poumeaud ^{[1
]}

Anna, Fontanier ^{[2
]}

Jeremie, Dion ^{[3
]}

Quentin, Mathevet ^{[2
]}

Olivier, Cointault ^{[4
]}

Emmanuelle, Uro-Coste ^{[5
]}

Celine, Marty ^{[2
]}

Florence, Dalenc ^{[1
]}

Pierre, Girardie ^{[6
]}

Anais, Rataboul ^{[1
]}

机构：

[1] Inst Univ Canc Toulouse Oncopole, Dept Med Oncol, Inst Claudius Regaud, Toulouse, France

[2] Inst Univ Canc Toulouse Oncopole, Dept Clin Pharm, Inst Claudius Regaud, Toulouse, France

[3] Univ Toulouse, Dept Internal Med & Clin Immunol, Ctr Hosp, Toulouse, France

[4] Univ Toulouse, Dept Nephrol, Ctr Hosp, Toulouse, France

[5] Inst Univ Canc Toulouse Oncopole, Dept Anatomo Pathol, Toulouse, France

[6] Univ Toulouse Purpan, Dept Neurol, Ctr Hosp, Toulouse, France

来源：

FRONTIERS IN ONCOLOGY | 2022年 / 12卷

关键词：

rhabdomyolysis; palbociclib; simvastatin; interaction; myositis; plasmatic exchange; 4/6 INHIBITOR PALBOCICLIB; BREAST-CANCER; EZETIMIBE; FULVESTRANT; COMBINATION; THERAPY;

D O I：

10.3389/fonc.2022.1026434

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report the fourth described case of severe toxic rhabdomyolysis occurring in an 81-year-old woman caused by the concomitant administration of palbociclib taken at the usual dosage (125 mg per day) and simvastatin. To the best of our knowledge, this is the first reported case successfully treated by plasma exchanges, with complete functional recovery within two months. The severity of this case justifies further consideration of pharmacokinetic interactions between palbociclib or other CDK-4-6 inhibitors and statins, which potentially increase the risk of an adverse event.

引用

页数：6

共 50 条

[21] Simvastatin/sodium fusidate interactionFatal rhabdomyolysis in an elderly patient: case report
Reactions Weekly, 2011, 1343 (1) : 28 - 28
[22] Simvastatin interactionInteraction with concomitant cyclosporin leading to fatal rhabdomyolysis: case report
Reactions Weekly, 2000, 799 (1) : 10 - 10
[23] Simvastatin interactionFirst report of an interaction with concomitant diltiazem leading to hepatitis and rhabdomyolysis: case report
Reactions Weekly, 2000, 832 (1) : 12 - 12
[24] Severe rhabdomyolysis-induced acute kidney injury following concomitant use of Genvoya® (EVG/COBI/FTC/TAF) and simvastatin; a case report
Rita Godinho
Serge Bugnon
Terezija Gracin
James Tataw
BMC Nephrology, 20
[25] Severe rhabdomyolysis-induced acute kidney injury following concomitant use of Genvoya® (EVG/COBI/FTC/TAF) and simvastatin; a case report
Godinho, Rita
Bugnon, Serge
Gracin, Terezija
Tataw, James
BMC NEPHROLOGY, 2019, 20 (1)
[26] Severe raltegravir-associated rhabdomyolysis: a case report and review of the literature
Croce, F.
Vitello, P.
Della Pria, A.
Riva, A.
Galli, M.
Antinori, S.
INTERNATIONAL JOURNAL OF STD & AIDS, 2010, 21 (11) : 783 - 785
[27] Colchicine triggered severe rhabdomyolysis after long-term low-dose simvastatin therapy: a case report
Frydrychowicz C.
Pasieka B.
Pierer M.
Mueller W.
Petros S.
Weidhase L.
Journal of Medical Case Reports, 11 (1) : 1 - 5
[28] SimvastatinAcute renal failure and severe rhabdomyolysis: case report
Reactions Weekly, 2009, 1245 (1) : 33 - 34
[29] Simvastatin interactionInteraction with concomitant ciclosporin leading to rhabdomyolysis in an elderly patient: case report
Reactions Weekly, 2006, 1083 (1) : 22 - 22
[30] Severe hypothyroidism-induced rhabdomyolysis: A case report
Baghi, Mohamed Abdunasser
Sirajudeen, Jaseem
Naushad, Vamanjore A.
Alarbi, Khaled S.
Benshaban, Nada
CLINICAL CASE REPORTS, 2021, 9 (12):

← 1 2 3 4 5 →