Severe toxic rhabdomyolysis under combined palbociclib and simvastatin treatment: A case report

被引：0

作者：

Francois, Poumeaud ^{[1
]}

Anna, Fontanier ^{[2
]}

Jeremie, Dion ^{[3
]}

Quentin, Mathevet ^{[2
]}

Olivier, Cointault ^{[4
]}

Emmanuelle, Uro-Coste ^{[5
]}

Celine, Marty ^{[2
]}

Florence, Dalenc ^{[1
]}

Pierre, Girardie ^{[6
]}

Anais, Rataboul ^{[1
]}

机构：

[1] Inst Univ Canc Toulouse Oncopole, Dept Med Oncol, Inst Claudius Regaud, Toulouse, France

[2] Inst Univ Canc Toulouse Oncopole, Dept Clin Pharm, Inst Claudius Regaud, Toulouse, France

[3] Univ Toulouse, Dept Internal Med & Clin Immunol, Ctr Hosp, Toulouse, France

[4] Univ Toulouse, Dept Nephrol, Ctr Hosp, Toulouse, France

[5] Inst Univ Canc Toulouse Oncopole, Dept Anatomo Pathol, Toulouse, France

[6] Univ Toulouse Purpan, Dept Neurol, Ctr Hosp, Toulouse, France

来源：

FRONTIERS IN ONCOLOGY | 2022年 / 12卷

关键词：

rhabdomyolysis; palbociclib; simvastatin; interaction; myositis; plasmatic exchange; 4/6 INHIBITOR PALBOCICLIB; BREAST-CANCER; EZETIMIBE; FULVESTRANT; COMBINATION; THERAPY;

D O I：

10.3389/fonc.2022.1026434

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report the fourth described case of severe toxic rhabdomyolysis occurring in an 81-year-old woman caused by the concomitant administration of palbociclib taken at the usual dosage (125 mg per day) and simvastatin. To the best of our knowledge, this is the first reported case successfully treated by plasma exchanges, with complete functional recovery within two months. The severity of this case justifies further consideration of pharmacokinetic interactions between palbociclib or other CDK-4-6 inhibitors and statins, which potentially increase the risk of an adverse event.

引用

页数：6

共 50 条

[1] Severe toxic rhabdomyolysis under combined palbociclib and simvastatin treatment: A case report (Dec, 10.3389/fonc.2022.1026434, 2022)
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