Distribution of vascular endothelial growth factor (VEGF) in prostate disease

被引：26

作者：

Walsh, K

Sriprasad, S

Hopster, D

Codd, J

Mulvin, D

机构：

[1] Kings Coll London Hosp, Dept Pathol, London, England

[2] Kings Coll London Hosp, Dept Urol, London, England

来源：

PROSTATE CANCER AND PROSTATIC DISEASES | 2002年 / 5卷 / 02期

关键词：

prostate; growth factor; immunocytochemistry;

D O I：

10.1038/sj.pcan.4500575

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Vascular endothelial growth factor (VEGF) is a heparin-binding polypeptide growth factor. It is a potent mitogen for endothelial cells. Immunohistochemical localisaition of VEGF was performed on 25 moderate to poorly differentiated stage T4 M + prostate cancer specimens and 30 benign prostatic hyperplasia (BPH) specimens. A positive result was indicated by area staining > 25% and + 2 or + 3 staining intensity. Positive epithelial staining was observed in 50% of BPH specimens and 56% of cancer specimens, while positive stromal staining was observed in 73% of BPH specimens and 30% of cancer specimens. This may reflect an active role for stromal VEGF in the pathological process of BPH.

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收藏

页码：119 / 122

页数：4

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