Distribution of vascular endothelial growth factor (VEGF) in prostate disease

被引：27

作者：

Walsh, K

Sriprasad, S

Hopster, D

Codd, J

Mulvin, D

机构：

[1] Kings Coll London Hosp, Dept Pathol, London, England

[2] Kings Coll London Hosp, Dept Urol, London, England

来源：

PROSTATE CANCER AND PROSTATIC DISEASES | 2002年 / 5卷 / 02期

关键词：

prostate; growth factor; immunocytochemistry;

D O I：

10.1038/sj.pcan.4500575

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Vascular endothelial growth factor (VEGF) is a heparin-binding polypeptide growth factor. It is a potent mitogen for endothelial cells. Immunohistochemical localisaition of VEGF was performed on 25 moderate to poorly differentiated stage T4 M + prostate cancer specimens and 30 benign prostatic hyperplasia (BPH) specimens. A positive result was indicated by area staining > 25% and + 2 or + 3 staining intensity. Positive epithelial staining was observed in 50% of BPH specimens and 56% of cancer specimens, while positive stromal staining was observed in 73% of BPH specimens and 30% of cancer specimens. This may reflect an active role for stromal VEGF in the pathological process of BPH.

引用

收藏

页码：119 / 122

页数：4

相关论文

共 30 条

[1] COMPARATIVE EXPRESSION OF FIBROBLAST GROWTH-FACTOR MESSENGER-RNAS IN BENIGN AND MALIGNANT BREAST DISEASE [J].

ANANDAPPA, SY ;

WINSTANLEY, JHR ;

LEINSTER, S ;

GREEN, B ;

RUDLAND, PS ;

BARRACLOUGH, R .

BRITISH JOURNAL OF CANCER, 1994, 69 (04) :772-776

[2]

[Anonymous], AHCPR PUBLICATION

[3] EXPRESSION OF THE VASCULAR-PERMEABILITY FACTOR VASCULAR ENDOTHELIAL GROWTH-FACTOR GENE IN CENTRAL-NERVOUS-SYSTEM NEOPLASMS [J].

BERKMAN, RA ;

MERRILL, MJ ;

REINHOLD, WC ;

MONACCI, WT ;

SAXENA, A ;

CLARK, WC ;

ROBERTSON, JT ;

ALI, IU ;

OLDFIELD, EH .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (01) :153-159

[4] EXPRESSION OF VASCULAR ENDOTHELIAL GROWTH-FACTOR AND ITS RECEPTORS FLT AND KDR IN OVARIAN-CARCINOMA [J].

BOOCOCK, CA ;

CHARNOCKJONES, DS ;

SHARKEY, AM ;

MCLAREN, J ;

BARKER, PJ ;

WRIGHT, KA ;

TWENTYMAN, PR ;

SMITH, SK .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1995, 87 (07) :506-516

[5]

BROWN LF, 1993, AM J PATHOL, V143, P1255

[6]

CUNHA GR, 1983, RECENT PROG HORM RES, V39, P559

[7] Vascular endothelial growth factor (VEGF) expression in human prostate cancer: In situ and in vitro expression of VEGF by human prostate cancer cells [J].

Ferrer, FA ;

Miller, LJ ;

Andrawis, RI ;

Kurtzman, SH ;

Albertsen, PC ;

Laudone, VP ;

Kreutzer, DL .

JOURNAL OF UROLOGY, 1997, 157 (06) :2329-2333

[8] A prospective study of the natural history of hematuria associated with benign prostatic hyperplasia and the effect of finasteride [J].

Foley, SJ ;

Soloman, LZ ;

Wedderburn, AW ;

Kashif, KM ;

Summerton, D ;

Basketter, V ;

Holmes, SAV .

JOURNAL OF UROLOGY, 2000, 163 (02) :496-498

[9] Expression of vascular endothelial growth factor mRNA in non-small-cell lung carcinomas [J].

Fontanini, G ;

Boldrini, L ;

Chinè, S ;

Pisaturo, F ;

Basolo, F ;

Calcinai, A ;

Lucchi, M ;

Mussi, A ;

Angeletti, CA ;

Bevilacqua, G .

BRITISH JOURNAL OF CANCER, 1999, 79 (02) :363-369

[10] BOTH V-HA-RAS AND V-RAF STIMULATE EXPRESSION OF THE VASCULAR ENDOTHELIAL GROWTH-FACTOR IN NIH 3T3 CELLS [J].

GRUGEL, S ;

FINKENZELLER, G ;

WEINDEL, K ;

BARLEON, B ;

MARME, D .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (43) :25915-25919