Distribution of vascular endothelial growth factor (VEGF) in prostate disease

被引:26
作者
Walsh, K
Sriprasad, S
Hopster, D
Codd, J
Mulvin, D
机构
[1] Kings Coll London Hosp, Dept Pathol, London, England
[2] Kings Coll London Hosp, Dept Urol, London, England
关键词
prostate; growth factor; immunocytochemistry;
D O I
10.1038/sj.pcan.4500575
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Vascular endothelial growth factor (VEGF) is a heparin-binding polypeptide growth factor. It is a potent mitogen for endothelial cells. Immunohistochemical localisaition of VEGF was performed on 25 moderate to poorly differentiated stage T4 M + prostate cancer specimens and 30 benign prostatic hyperplasia (BPH) specimens. A positive result was indicated by area staining > 25% and + 2 or + 3 staining intensity. Positive epithelial staining was observed in 50% of BPH specimens and 56% of cancer specimens, while positive stromal staining was observed in 73% of BPH specimens and 30% of cancer specimens. This may reflect an active role for stromal VEGF in the pathological process of BPH.
引用
收藏
页码:119 / 122
页数:4
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