Neoadjuvant Therapy in the Treatment of Breast Cancer

被引：116

作者：

Teshome, Mediget ^{[1
]}

Hunt, Kelly K. ^{[1
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA

来源：

SURGICAL ONCOLOGY CLINICS OF NORTH AMERICA | 2014年 / 23卷 / 03期

关键词：

Breast cancer; Neoadjuvant chemotherapy; Preoperative chemotherapy; Pathologic complete response; PATHOLOGICAL COMPLETE RESPONSE; CHEMOTHERAPY PLUS TRASTUZUMAB; LOCAL-REGIONAL RECURRENCE; III RANDOMIZED GEPARTRIO; HORMONE-RECEPTOR STATUS; LYMPH-NODE SURGERY; PREOPERATIVE CHEMOTHERAPY; PHASE-II; PROGNOSTIC VALUE; PRIMARY TUMOR;

D O I：

10.1016/j.soc.2014.03.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neoadjuvant systemic therapy in breast cancer treatment was initially utilized for inoperable disease. However, several randomized prospective studies have demonstrated comparable survival with adjuvant chemotherapy in early-stage, operable breast cancer while also decreasing tumor size facilitating breast conservation without significant increases in local recurrence. Response to therapy can predict outcome, with improved survival associated with pathologic complete response (pCR). Triple negative and HER2-positive subtypes show increased pCR rates. A multidisciplinary approach is necessary with neoadjuvant treatment. This can improve rates of breast conservation, provide insights into tumor biology and predict patient outcomes.

引用

页码：505 / +

页数：21

共 65 条

[1] Evaluation of the MD Anderson Prognostic Index for Local-Regional Recurrence After Breast Conserving Therapy in Patients Receiving Neoadjuvant Chemotherapy [J].

Akay, Catherine L. ;

Meric-Bernstam, Funda ;

Hunt, Kelly K. ;

Grubbs, Elizabeth G. ;

Bedrosian, Isabelle ;

Tucker, Susan L. ;

Kuerer, Henry M. ;

Hoffman, Karen E. ;

Babiera, Gildy V. ;

Strom, Eric A. ;

Buchholz, Thomas A. ;

Mittendorf, Elizabeth A. .

ANNALS OF SURGICAL ONCOLOGY, 2012, 19 (03) :901-907

[2] The Role for Sentinel Lymph Node Dissection after Neoadjuvant Chemotherapy in Patients who Present with Node-Positive Breast Cancer [J].

Alvarado, Rosalinda ;

Yi, Min ;

Le-Petross, Huong ;

Gilcrease, Michael ;

Mittendorf, Elizabeth A. ;

Bedrosian, Isabelle ;

Hwang, Rosa F. ;

Caudle, Abigail S. ;

Babiera, Gildy V. ;

Akins, Jeri S. ;

Kuerer, Henry M. ;

Hunt, Kelly K. .

ANNALS OF SURGICAL ONCOLOGY, 2012, 19 (10) :3177-3184

[3] Lapatinib with trastuzumab for HER2-positive early breast cancer (NeoALTTO): a randomised, open-label, multicentre, phase 3 trial [J].

Baselga, Jose ;

Bradbury, Ian ;

Eidtmann, Holger ;

Di Cosimo, Serena ;

de Azambuja, Evandro ;

Aura, Claudia ;

Gomez, Henry ;

Dinh, Phuong ;

Fauria, Karine ;

Van Dooren, Veerle ;

Aktan, Gursel ;

Goldhirsch, Aron ;

Chang, Tsai-Wang ;

Horvath, Zsolt ;

Coccia-Portugal, Maria ;

Domont, Julien ;

Tseng, Ling-Min ;

Kunz, Georg ;

Sohn, Joo Hyuk ;

Semiglazov, Vladimir ;

Lerzo, Guillermo ;

Palacova, Marketa ;

Probachai, Volodymyr ;

Pusztai, Lajos ;

Untch, Michael ;

Gelber, Richard D. ;

Piccart-Gebhart, Martine .

LANCET, 2012, 379 (9816) :633-640

[4] Sentinel Lymph Node Surgery After Neoadjuvant Chemotherapy in Patients With Node-Positive Breast Cancer The ACOSOG Z1071 (Alliance) Clinical Trial [J].

Boughey, Judy C. ;

Suman, Vera J. ;

Mittendorf, Elizabeth A. ;

Ahrendt, Gretchen M. ;

Wilke, Lee G. ;

Taback, Bret ;

Leitch, A. Marilyn ;

Kuerer, Henry M. ;

Bowling, Monet ;

Flippo-Morton, Teresa S. ;

Byrd, David R. ;

Ollila, David W. ;

Julian, Thomas B. ;

McLaughlin, Sarah A. ;

McCall, Linda ;

Symmans, W. Fraser ;

Le-Petross, Huong T. ;

Haffty, Bruce G. ;

Buchholz, Thomas A. ;

Nelson, Heidi ;

Hunt, Kelly K. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2013, 310 (14) :1455-1461

[5] Neoadjuvant therapy with paclitaxel followed by 5-fluorouracil, epirubicin, and cyclophosphamide chemotherapy and concurrent trastuzumab in human epidermal growth factor receptor 2-positive operable breast cancer: An update of the initial randomized study population and data of additional patients treated with the same regimen [J].

Buzdar, Aman U. ;

Valero, Vicente ;

Ibrahim, Nuhad K. ;

Francis, Deborah ;

Broglio, Kristine R. ;

Theriault, Richard L. ;

Pusztai, Lajos ;

Green, Marjorie C. ;

Singletary, Sonja E. ;

Hunt, Kelly K. ;

Sahin, Aysegul A. ;

Esteva, Francisco ;

Symmans, William F. ;

Ewer, Michael S. ;

Buchholz, Thomas A. ;

Hortobagyi, Gabriel N. .

CLINICAL CANCER RESEARCH, 2007, 13 (01) :228-233

[6] Significantly higher pathologic complete remission rate after neoadjuvant therapy with trastuzumab, paclitaxel, and epirubicin chemotherapy: Results of a randomized trial in human epidermal growth factor receptor 2-positive operable breast cancer [J].

Buzdar, AU ;

Ibrahim, NK ;

Francis, D ;

Booser, DJ ;

Thomas, ES ;

Theriault, RL ;

Pusztai, L ;

Green, MC ;

Arun, BK ;

Giordano, SH ;

Cristofanilli, M ;

Frye, DK ;

Smith, TL ;

Hunt, KK ;

Singletary, SE ;

Sahin, AA ;

Ewer, MS ;

Buchholz, TA ;

Berry, D ;

Hortobagyi, GN .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (16) :3676-3685

[7] The triple negative paradox: Primary tumor chemosensitivity of breast cancer subtypes [J].

Carey, Lisa A. ;

Dees, E. Claire ;

Sawyer, Lynda ;

Gatti, Lisa ;

Moore, Dominic T. ;

Collichio, Frances ;

Ollila, David W. ;

Sartor, Carolyn I. ;

Graham, Mark L. ;

Perou, Charles M. .

CLINICAL CANCER RESEARCH, 2007, 13 (08) :2329-2334

[8] Comparison of anastrozole versus tamoxifen as preoperative therapy in postmenopausal women with hormone receptor-positive breast cancer - The Pre-Operative "Arimidex" Compared to Tamoxilen (PROAC7) trial [J].

Cataliotti, L ;

Buzdar, AU ;

Noguchi, S ;

Bines, J ;

Takatsuka, Y ;

Petrakova, K ;

Dube, P ;

de Oliveira, CT .

CANCER, 2006, 106 (10) :2095-2103

[9] Differential Response of Triple-Negative Breast Cancer to a Docetaxel and Carboplatin-Based Neoadjuvant Treatment [J].

Chang, Helena R. ;

Glaspy, John ;

Allison, Mary Ann ;

Kass, Frederic C. ;

Elashoff, Robert ;

Chung, Debra U. ;

Gornbein, Jeffrey .

CANCER, 2010, 116 (18) :4227-4237

[10] Breast conservation after neoadjuvant chemotherapy - A prognostic index for clinical decision-making [J].

Chen, AM ;

Meric-Bernstam, F ;

Hunt, KK ;

Thames, HD ;

Outlaw, ED ;

Strom, EA ;

McNeese, MD ;

Kuerer, HM ;

Ross, MI ;

Singletary, SE ;

Ames, FC ;

Feig, BW ;

Sahin, AA ;

Perkins, GH ;

Babiera, G ;

Hortobagyi, GN ;

Buchholz, TA .

CANCER, 2005, 103 (04) :689-695

← 1 2 3 4 5 6 7 →