Studies on the interaction of antibiotic drug rifampin with DNA and influence of bivalent metal ions on binding affinity

被引：22

作者：

Shahabadi, Nahid ^{[1
,2
]}

Shiri, Farshad ^{[1
,2
]}

Hadidi, Saba ^{[1
,2
]}

机构：

[1] Razi Univ, Fac Chem, Dept Inorgan Chem, Kermanshah, Iran

[2] Kermanshah Univ Med Sci, MBRC, Kermanshah, Iran

来源：

SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY | 2019年 / 219卷

关键词：

Rifampin; Groove binding; Bivalent metal ions; DNA interaction; HUMAN SERUM-ALBUMIN; CALF THYMUS DNA; SPECTROSCOPIC CHARACTERIZATION; ORGANOTIN(IV) DERIVATIVES; BIOLOGICAL SCREENINGS; MOLECULAR DOCKING; VACCINIA VIRUS; STRANDED-DNA; ANTICANCER; EXPLORATION;

D O I：

10.1016/j.saa.2019.04.059

中图分类号：

O433 [光谱学];

学科分类号：

0703 ; 070302 ;

摘要：

In this paper, the interaction between rifampin, a known antibiotic used against tuberculosis, and DNA helix is investigated by applying multiple biophysical and molecular modelling approaches in an aqueous solution at pH 7.4 and 5. It was proved that the fluorescence quenching of labeled probe DNA by rifampin is a result of the complex formation of rifampin in groove of DNA. Binding parameters were calculated using the logarithmic Hill equation to provide a quantitative term of the binding affinity between rifampin and DNA sites. The resulting Delta H-0= -122.76 +/- 0.07 kJ/mol and Delta S-0 = -308.19 +/- 238.78 J/mol K confirms the role of the Van der Waals' forces and hydrogen bonding in the rifampin-DNA complexation. Furthermore, the influence of bivalent metal ions on the binding affinity was resulted in order of Cu(II) > Ca(II) > Co(II) > Zn(II). (C) 2019 Elsevier B.V. All rights reserved.

引用

页码：195 / 201

页数：7

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