Role of activating transcription factor 3 protein ATF3 in necrosis and apoptosis induced by 5-fluoro-20-deoxyuridine

被引：23

作者：

Sato, Akira ^{[1
,2
]}

Nakama, Kentaro ^{[1
]}

Watanabe, Hiroki ^{[1
]}

Satake, Akito ^{[1
]}

Yamamoto, Akihiro ^{[1
]}

Omi, Takuya ^{[1
]}

Hiramoto, Akiko ^{[1
]}

Masutani, Mitsuko ^{[2
]}

Wataya, Yusuke ^{[1
]}

Kim, Hye-Sook ^{[1
]}

机构：

[1] Okayama Univ, Fac Pharmaceut Sci, Kita Ku, Okayama 7008530, Japan

[2] Natl Canc Ctr, Res Inst, Div Genome Stabil Res, Chuo Ku, Tokyo 104, Japan

来源：

FEBS JOURNAL | 2014年 / 281卷 / 07期

关键词：

activating transcription factor3 (ATF3); apoptosis; cell death; heat shock protein90 (HSP90); necrosis; CELL-DEATH; THYMIDYLATE SYNTHETASE; HSP90; 5-FLUORO-2'-DEOXYURIDINE; GENE; UBIQUITINATION; DEGRADATION; HOMEOSTASIS; DISRUPTION; INHIBITORS;

D O I：

10.1111/febs.12752

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Necrosis and apoptosis are the two major forms of cell death. We have studied the mechanisms that regulate the cell death observed during treatment of mouse cancer cell line FM3A with the anticancer drug 5-fluoro-2-deoxyuridine (FUdR). To detect causal differences between necrosis and apoptosis, we exploited the necrosis in original clone F28-7 and the apoptosis in its variant F28-7-A that occur on treatment with FUdR. Activating transcription factor3 (ATF3) was strongly induced during necrosis but not apoptosis. In addition, we found that ATF3 expression is regulated by heat shock protein90 (HSP90) at the mRNA stage. Knockdown of Atf3 by siRNA in the F28-7 cells resulted in apoptotic morphology rather than necrotic morphology. These results suggest that ATF3 is a cell-death regulator in necrosis and apoptosis.

引用

页码：1892 / 1900

页数：9

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