One-Step Catalytic Synthesis of Alkyl-Substituted Quinolines

被引：76
|
作者：
Meyet, Courtney E. [1 ]
Larsen, Catharine H. [1 ]
机构：
[1] Univ Calif Riverside, Dept Chem, Riverside, CA 92521 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 20期
关键词：
3-COMPONENT REACTION; ANTITUBERCULOSIS AGENTS; CONJUGATED POLYMERS; CHEMICAL-SYNTHESIS; GREEN CHEMISTRY; DERIVATIVES; ALDEHYDES; AMINES; PROPARGYLAMINES; DISCOVERY;
D O I：
10.1021/jo5015883
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Difficult-to-access alkyl-substituted quinolines are formed directly from commercially available anilines, aldehydes, and alkynes bearing a variety of substituents. Copper(II) triflate catalyzes this three-component coupling without ligand, cocatalyst, solvent, or inert atmosphere. In addition, a two-component Povarov reaction forms 2,3-dialkyl quinolines under the same green conditions that enable the selective three-component synthesis of 2-alkyl quinolines as well as more common aryl quinolines.
引用
收藏
页码：9835 / 9841
页数：7
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