One-Step Catalytic Synthesis of Alkyl-Substituted Quinolines

被引：76

作者：

Meyet, Courtney E. ^{[1
]}

Larsen, Catharine H. ^{[1
]}

机构：

[1] Univ Calif Riverside, Dept Chem, Riverside, CA 92521 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 79卷 / 20期

关键词：

3-COMPONENT REACTION; ANTITUBERCULOSIS AGENTS; CONJUGATED POLYMERS; CHEMICAL-SYNTHESIS; GREEN CHEMISTRY; DERIVATIVES; ALDEHYDES; AMINES; PROPARGYLAMINES; DISCOVERY;

D O I：

10.1021/jo5015883

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Difficult-to-access alkyl-substituted quinolines are formed directly from commercially available anilines, aldehydes, and alkynes bearing a variety of substituents. Copper(II) triflate catalyzes this three-component coupling without ligand, cocatalyst, solvent, or inert atmosphere. In addition, a two-component Povarov reaction forms 2,3-dialkyl quinolines under the same green conditions that enable the selective three-component synthesis of 2-alkyl quinolines as well as more common aryl quinolines.

引用

页码：9835 / 9841

页数：7

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