TGF-β signaling pathway as a pharmacological target in liver diseases

被引：33
|
作者：
Zhang, Sen [1 ]
Sun, Wu-Yi [1 ]
Wu, Jing-Jing [1 ]
Wei, Wei [1 ]
机构：
[1] Anhui Med Univ, Inst Clin Pharmacol, Key Lab Antiinflammatory & Immune Med, Minist Educ, Hefei 230032, Anhui, Peoples R China
来源：
PHARMACOLOGICAL RESEARCH | 2014年 / 85卷
基金：
高等学校博士学科点专项科研基金;
关键词：
Transforming growth factor beta; Signaling pathway; Liver diseases; Pharmacological target; Targeted drugs; GROWTH-FACTOR-BETA; RECEPTOR KINASE DOMAIN; HEPATOCELLULAR-CARCINOMA; MESENCHYMAL TRANSITION; CROSS-TALK; ACTIVIN-A; INHIBITOR; CANCER; FIBROGENESIS; PROGRESSION;
D O I：
10.1016/j.phrs.2014.05.005
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Transforming growth factor beta (TGF-beta) belongs to a class of pleiotropic cytokines that are involved in the processes of embryonic development, wound healing, cell proliferation, and differentiation. Moreover, TGF-beta is also regarded as a central regulator in the pathogenesis and development of various liver diseases because it contributes to almost all of the stages of disease progression. A range of liver cells are considered to secrete TGF-beta ligands and express related receptors and, consequently, play a crucial role in the progression of liver disease via different signal pathways. In this manuscript, we review the role of the TGF-beta signaling pathway in liver disease and the potential of targeting the TGF-beta signaling in the pharmacological treatment of liver diseases. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：15 / 22
页数：8
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