Molecular markers in ALL: Clinical implications

被引：33

作者：

Kimura, Shunsuke ^{[1
]}

Mullighan, Charles G. ^{[1
]}

机构：

[1] St Jude Childrens Res Hosp, Hematol Malignancies Program, Dept Pathol, 262 Danny Thomas Pl,Mail Stop 342, Memphis, TN 38105 USA

来源：

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY | 2020年 / 33卷 / 03期

关键词：

Acute lymphoblastic leukemia; ALL; B-ALL; T-ALL; DUX4; ETV6-RUNX1; Hyperdiploid; Hypodiploid; KMT2A; TCF3; IKZF1; MEF2D; PAX5; Ph-like; ZNF384; ETP; TLX1/3; TAL1; Relapse; ACUTE LYMPHOBLASTIC-LEUKEMIA; PHILADELPHIA CHROMOSOME-LIKE; GENOMIC LANDSCAPE; CLONAL EVOLUTION; INTRACHROMOSOMAL AMPLIFICATION; GENE-EXPRESSION; PH PLUS; CHILDHOOD; MUTATIONS; RISK;

D O I：

10.1016/j.beha.2020.101193

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer and remains a main cause of death in children despite recent improvements in cure rates. In the past decade, development of massively parallel sequencing has enabled large scale genome profiling studies of ALL, which not only led to identification of new subtypes in both B-cell precursor ALL (BCP-ALL) and T-cell ALL (T-ALL), but has also identified potential new therapeutic approaches to target vulnerabilities of many subtypes. Several of these approaches have been validated in preclinical models and are now being formally evaluated in prospective clinical trials. In this review, we provide an overview of the recent advances in our knowledge of genomic bases of BCP-ALL, T-ALL, and relapsed ALL, and discuss their clinical implications.

引用

页数：12

共 107 条

[1] The genetic basis and cell of origin of mixed phenotype acute leukaemia [J].

Alexander, Thomas B. ;

Gu, Zhaohui ;

Iacobucci, Ilaria ;

Dickerson, Kirsten ;

Choi, John K. ;

Xu, Beisi ;

Payne-Turner, Debbie ;

Yoshihara, Hiroki ;

Loh, Mignon L. ;

Horan, John ;

Buldini, Barbara ;

Basso, Giuseppe ;

Elitzur, Sarah ;

de Haas, Valerie ;

Zwaan, C. Michel ;

Yeoh, Allen ;

Reinhardt, Dirk ;

Tomizawa, Daisuke ;

Kiyokawa, Nobutaka ;

Lammens, Tim ;

De Moerloose, Barbara ;

Catchpoole, Daniel ;

Hori, Hiroki ;

Moorman, Anthony ;

Moore, Andrew S. ;

Hrusak, Ondrej ;

Meshinchi, Soheil ;

Orgel, Etan ;

Devidas, Meenakshi ;

Borowitz, Michael ;

Wood, Brent ;

Heerema, Nyla A. ;

Carrol, Andrew ;

Yang, Yung-Li ;

Smith, Malcolm A. ;

Davidsen, Tanja M. ;

Hermida, Leandro C. ;

Gesuwan, Patee ;

Marra, Marco A. ;

Ma, Yussanne ;

Mungall, Andrew J. ;

Moore, Richard A. ;

Jones, Steven J. M. ;

Valentine, Marcus ;

Janke, Laura J. ;

Rubnitz, Jeffrey E. ;

Pui, Ching-Hon ;

Ding, Liang ;

Liu, Yu ;

Zhang, Jinghui .

NATURE, 2018, 562 (7727) :373-+

[2] Genetic variegation of clonal architecture and propagating cells in leukaemia [J].

Anderson, Kristina ;

Lutz, Christoph ;

van Delft, Frederik W. ;

Bateman, Caroline M. ;

Guo, Yanping ;

Colman, Susan M. ;

Kempski, Helena ;

Moorman, Anthony V. ;

Titley, Ian ;

Swansbury, John ;

Kearney, Lyndal ;

Enver, Tariq ;

Greaves, Mel .

NATURE, 2011, 469 (7330) :356-+

[3] The landscape of somatic mutations in infant MLL-rearranged acute lymphoblastic leukemias [J].

Andersson, Anna K. ;

Ma, Jing ;

Wang, Jianmin ;

Chen, Xiang ;

Gedman, Amanda Larson ;

Dang, Jinjun ;

Nakitandwe, Joy ;

Holmfeldt, Linda ;

Parker, Matthew ;

Easton, John ;

Huether, Robert ;

Kriwacki, Richard ;

Rusch, Michael ;

Wu, Gang ;

Li, Yongjin ;

Mulder, Heather ;

Raimondi, Susana ;

Pounds, Stanley ;

Kang, Guolian ;

Shi, Lei ;

Becksfort, Jared ;

Gupta, Pankaj ;

Payne-Turner, Debbie ;

Vadodaria, Bhavin ;

Boggs, Kristy ;

Yergeau, Donald ;

Manne, Jayanthi ;

Song, Guangchun ;

Edmonson, Michael ;

Nagahawatte, Panduka ;

Wei, Lei ;

Cheng, Cheng ;

Pei, Deqing ;

Sutton, Rosemary ;

Venn, Nicola C. ;

Chetcuti, Albert ;

Rush, Amanda ;

Catchpoole, Daniel ;

Heldrup, Jesper ;

Fioretos, Thoas ;

Lu, Charles ;

Ding, Li ;

Pui, Ching-Hon ;

Shurtleff, Sheila ;

Mullighan, Charles G. ;

Mardis, Elaine R. ;

Wilson, Richard K. ;

Gruber, Tanja A. ;

Zhang, Jinghui ;

Downing, James R. .

NATURE GENETICS, 2015, 47 (04) :330-U192

[4] PAX5 biallelic genomic alterations define a novel subgroup of B-cell precursor acute lymphoblastic leukemia [J].

Bastian, Lorenz ;

Schroeder, Michael P. ;

Eckert, Cornelia ;

Schlee, Cornelia ;

Tanchez, Jutta Ortiz ;

Kaempf, Sebastian ;

Wagner, Dimitrios L. ;

Schulze, Veronika ;

Isaakidis, Konstandina ;

Lazaro-Navarro, Juan ;

Haenzelmann, Sonja ;

James, Alva Rani ;

Ekici, Arif ;

Burmeister, Thomas ;

Schwartz, Stefan ;

Schrappe, Martin ;

Horstmann, Martin ;

Vosberg, Sebastian ;

Krebs, Stefan ;

Blum, Helmut ;

Hecht, Jochen ;

Greif, Philipp A. ;

Rieger, Michael A. ;

Brueggemann, Monika ;

Goekbuget, Nicola ;

Neumann, Martin ;

Baldus, Claudia D. .

LEUKEMIA, 2019, 33 (08) :1895-1909

[5] The genetics and mechanisms of T cell acute lymphoblastic leukaemia [J].

Belver, Laura ;

Ferrando, Adolfo .

NATURE REVIEWS CANCER, 2016, 16 (08) :494-507

[6] Crosstalk between ROR1 and the Pre-B Cell Receptor Promotes Survival of t(1;19) Acute Lymphoblastic Leukemia [J].

Bicocca, Vincent T. ;

Chang, Bill H. ;

Masouleh, Behzad Kharabi ;

Muschen, Markus ;

Loriaux, Marc M. ;

Druker, Brian J. ;

Tyner, Jeffrey W. .

CANCER CELL, 2012, 22 (05) :656-667

[7] Natural history and cell of origin of TCF3-ZNF384 and PTPN11 mutations in monozygotic twins with concordant BCP-ALL [J].

Bueno, Clara ;

Ramon Tejedor, J. ;

Bashford-Rogers, Rachael ;

Gonzalez-Silva, Laura ;

Valdes-Mas, Rafael ;

Agraz-Doblas, Antonio ;

Diaz de la Guardia, Rafael ;

Ribera, Jordi ;

Zamora, Lurdes ;

Bilhou-Nabera, Chrystele ;

Abermil, Nassera ;

Guermouche, Helene ;

Gouache, Elodie ;

Leverger, Guy ;

Fraga, Mario F. ;

Fernandez, Agustin F. ;

Ballerini, Paola ;

Varela, Ignacio ;

Menendez, Pablo .

BLOOD, 2019, 134 (11) :900-905

[8] Imatinib resistant BCR-ABL1 mutations at relapse in children with Ph plus ALL: a Children's Oncology Group (COG) study [J].

Chang, Bill H. ;

Willis, Stephanie G. ;

Stork, Linda ;

Hunger, Stephen P. ;

Carroll, William L. ;

Camitta, Bruce M. ;

Winick, Naomi J. ;

Druker, Brian J. ;

Schultz, Kirk R. .

BRITISH JOURNAL OF HAEMATOLOGY, 2012, 157 (04) :507-510

[9] DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia [J].

Chen, Chun-Wei ;

Koche, Richard P. ;

Sinha, Amit U. ;

Deshpande, Aniruddha J. ;

Zhu, Nan ;

Eng, Rowena ;

Doench, John G. ;

Xu, Haiming ;

Chu, Scott H. ;

Qi, Jun ;

Wang, Xi ;

Delaney, Christopher ;

Bernt, Kathrin M. ;

Root, David E. ;

Hahn, William C. ;

Bradner, James E. ;

Armstrong, Scott A. .

NATURE MEDICINE, 2015, 21 (04) :335-+

[10] Leukemia-associated NOTCH1 alleles are weak tumor initiators but accelerate K-ras-initiated leukemia [J].

Chiang, Mark Y. ;

Xu, Lanwei ;

Shestova, Olga ;

Histen, Gavin ;

L'Heureux, Sarah ;

Romany, Candice ;

Childs, M. Eden ;

Gimotty, Phyllis A. ;

Aster, Jon C. ;

Pear, Warren S. .

JOURNAL OF CLINICAL INVESTIGATION, 2008, 118 (09) :3181-3194

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