HLA Restriction of Carbamazepine-Specific T-Cell Clones from an HLA-A*31:01-Positive Hypersensitive Patient

被引：30

作者：

Lichtenfels, Maike ^{[1
]}

Farrell, John ^{[1
]}

Ogese, Monday O. ^{[1
]}

Bell, Catherine C. ^{[1
]}

Eckle, Sidonia ^{[2
]}

McCluskey, James ^{[2
]}

Park, B. Kevin ^{[1
]}

Alfirevic, Ana ^{[1
]}

Naisbitt, Dean J. ^{[1
]}

Pirmohamed, Munir ^{[1
]}

机构：

[1] Univ Liverpool, Dept Mol & Clin Pharmacol, Liverpool L69 3GE, Merseyside, England

[2] Univ Melbourne, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 2014年 / 27卷 / 02期

基金：

英国医学研究理事会;

关键词：

ADVERSE DRUG-REACTIONS; STEVENS-JOHNSON SYNDROME; JAPANESE POPULATION;

D O I：

10.1021/tx400460w

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

HLA-A*31:01 is associated with carbamazepine (CBZ) hypersensitivity in Caucasian and Japanese populations. Herein, we show that HLA-A*31:01+ restricted the activation of carbamazepine-specific CD8(+) T-cells, which provides an immunological basis for the genetic association. Furthermore, CD4(+) T-cells were activated with carbamazepine in a HLA-DRB1*04:04-restricted manner, indicating that a common HLA haplotype may contribute to the multiclonal T-cell response seen in European patients with CBZ hypersensitivity.

引用

页码：175 / 177

页数：3

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