Novel facile synthesis of 2,2,4 substituted 1,2-dihydroquinolines via a modified Skraup reaction

被引：177

作者：

Theoclitou, ME ^{[1
]}

Robinson, LA ^{[1
]}

机构：

[1] Bristol Myers Squibb Co, Pharma Res Labs, San Diego, CA 92121 USA

来源：

TETRAHEDRON LETTERS | 2002年 / 43卷 / 21期

关键词：

D O I：

10.1016/S0040-4039(02)00614-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A variety of 2.2.4 subitituted 1.2-dihydroquinolines were synthesized from substituted anilines or aminoheterocycles and the corresponding ketones in good yield via the use of lanthanide catalysts and microwave technology. This method can be readily applied to the general synthesis of combinational libraries of dihydroquinolines. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：3907 / 3910

页数：4

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