The application of high hydrostatic pressure ( HHP) processing of food to extracting lycopene from tomato paste waste was studied. Various experimental conditions of HHP processing process, such as solvents ( chloroform, 95% ethanol and distilled water), ethanol concentration ( 45-95%, v/v), pressure ( 100-600MPa), duration ( 1-10 min) and solid/liquid ratio ( 1: 1 to 1: 8 g/ml), were investigated to optimize the extraction process. The experimental results of HHP showed that more lycopene can be extracted from tomato paste waste in only 1 min at room temperature without any heating process. The highest recovery ( 92%) was obtained by performing the extractions at 500MPa pressure, 1 min duration, 75% ethanol concentration, and 1: 6 ( g/ml) solid/ liquid ratio. From the viewpoints of extraction time, the extraction yield and the extraction efficiency, extraction by HHP shows a bright prospect for extracting lycopene from tomato paste waste.