An efficient and facile synthesis of benzimidazo [1,2-a]benzimidazoles via copper-catalyzed domino addition/double cyclization

被引：20

作者：

Yuan, Guodong ^{[1
]}

Liu, Haiquan ^{[1
]}

Gao, Jilong ^{[1
]}

Xu, Hongjuan ^{[1
]}

Jiang, Liu ^{[1
]}

Wang, Xiaoxia ^{[1
]}

Lv, Xin ^{[1
]}

机构：

[1] Zhejiang Normal Univ, Coll Chem & Life Sci, Zhejiang Key Lab React Chem Solid Surfaces, Jinhua 321004, Peoples R China

来源：

RSC ADVANCES | 2014年 / 4卷 / 42期

基金：

中国国家自然科学基金;

关键词：

PHARMACOLOGICAL-ACTIVITY; DERIVATIVES; VERSATILE; AGENTS; DNA;

D O I：

10.1039/c4ra01181c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A copper-catalyzed synthesis of benzimidazo[1,2-a]benzimidazoles by domino addition/double cyclization of bis-(o-haloaryl)carbodiimides with primary amines was developed. A variety of the desired polycyclic benzimidazoles were efficiently and facilely assembled. Multibonds and polycyclic moieties were directly constructed in one pot. 2-Bromo-2'-iodo-diarylcarbodiimides gave good selectivity.

引用

页码：21904 / 21908

页数：5

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