Subependymal giant cell astrocytoma with cranial and spinal metastases in a patient with tuberous sclerosis - Case report

被引：24

作者：

Telfeian, AE ^{[1
]}

Judkins, A

Younkin, D

Pollock, AN

Crino, P

机构：

[1] Childrens Hosp Philadelphia, Div Neurosurg, Dept Pathol, Philadelphia, PA 19104 USA

[2] Childrens Hosp Philadelphia, Div Neurosurg, Dept Neurol, Philadelphia, PA 19104 USA

[3] Childrens Hosp Philadelphia, Div Neurosurg, Dept Radiol, Philadelphia, PA 19104 USA

[4] Hosp Univ Penn, Sch Med, Dept Neurol, Philadelphia, PA 19104 USA

来源：

JOURNAL OF NEUROSURGERY | 2004年 / 100卷 / 05期

关键词：

tuberous sclerosis; subependymal giant cell tumor; epilepsy; pediatric neurosurgery;

D O I：

10.3171/ped.2004.100.5.0498

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This 17-year-old male patient with tuberous sclerosis developed increased headaches and lethargy. Magnetic resonance imaging of the brain revealed increased ventricle size and increased size of a subependymal giant cell astrocytoma at the foramen of Monro, as well as spinal cord metastases of giant cell tumors. Decompressive surgery of the foramen of Monro lesion resulted in temporary resolution of the hydrocephalus. Increased Ki-67 labeling of tumor as well as rare spinal enhancement both possibly indicated malignant features for this entity.

引用

页码：498 / 500

页数：3

共 14 条

[1]

Baron Y, 1999, AM J NEURORADIOL, V20, P907

[2] LEPTOMENINGEAL DISSEMINATION OF LOW-GRADE GLIOMAS IN CHILDHOOD [J].

CIVITELLO, LA ;

PACKER, RJ ;

RORKE, LB ;

SIEGEL, K ;

SUTTON, LN ;

SCHUT, L .

NEUROLOGY, 1988, 38 (04) :562-566

[3] Subependymal giant cell astrocytoma in children with tuberous sclerosis [J].

Cuccia, V ;

Zuccaro, G ;

Sosa, F ;

Monges, J ;

Lubienieky, F ;

Taratuto, AL .

CHILDS NERVOUS SYSTEM, 2003, 19 (04) :232-243

[4] Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2 [J].

Garami, A ;

Zwartkruis, FJT ;

Nobukuni, T ;

Joaquin, M ;

Roccio, M ;

Stocker, H ;

Kozma, SC ;

Hafen, E ;

Bos, JL ;

Thomas, G .

MOLECULAR CELL, 2003, 11 (06) :1457-1466

[5]

Koprowski C, 1983, Pediatr Pathol, V1, P474

[6] Markers of cellular proliferation are expressed in cortical tubers [J].

Lee, A ;

Maldonado, M ;

Baybis, M ;

Walsh, CA ;

Scheithauer, B ;

Yeung, R ;

Parent, J ;

Weiner, HL ;

Crino, PB .

ANNALS OF NEUROLOGY, 2003, 53 (05) :668-673

[7] Glioblastoma following radiotherapy in a patient with tuberous sclerosis - Case report [J].

Matsumura, H ;

Takimoto, H ;

Shimada, N ;

Hirata, M ;

Ohnishi, T ;

Hayakawa, T .

NEUROLOGIA MEDICO-CHIRURGICA, 1998, 38 (05) :287-291

[8]

MONTAGNE J, 2001, SCI STKE, V105, pPEO6

[9] Early diagnosis of subependymal giant cell astrocytoma in children with tuberous sclerosis [J].

Nabbout, R ;

Santos, M ;

Rolland, Y ;

Delalande, O ;

Dulac, O ;

Chiron, C .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1999, 66 (03) :370-375

[10] Tuberous sclerosis complex consensus conference: Revised clinical diagnostic criteria [J].

Roach, ES ;

Gomez, MR ;

Northrup, H .

JOURNAL OF CHILD NEUROLOGY, 1998, 13 (12) :624-628

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