Production of no-carrier-added 64Cu and applications to molecular imaging by PET and PETIS as a biomedical tracer

被引：23

作者：

Watanabe, S. ^{[1
]}

Iida, Y. ^{[2
,3
]}

Suzui, N. ^{[1
]}

Katabuchi, T. ^{[5
]}

Ishii, S. ^{[1
]}

Kawachi, N. ^{[1
]}

Hanaoka, H. ^{[2
]}

Watanabe, S. ^{[1
]}

Matsuhashi, S. ^{[1
]}

Endo, K. ^{[3
,4
]}

Ishioka, N. S. ^{[1
]}

机构：

[1] Japan Atom Energy Agcy, Plant Positron Imaging Grp, Quantum Beam Sci Directorate, Takasaki, Gunma 3701292, Japan

[2] Gunma Univ, Grad Sch Med, Dept Bioimaging Informat Anal, Gunma 3718511, Japan

[3] Gunma Univ, Grad Sch Med, 21st Century COE Program, Gunma 3718511, Japan

[4] Gunma Univ, Grad Sch Med, Dept Diagnost Radiol & Nucl Med, Gunma 3718511, Japan

[5] Tokyo Inst Technol, Nucl Reactors Res Lab, Meguro Ku, Tokyo 1528550, Japan

来源：

JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY | 2009年 / 280卷 / 01期

关键词：

EXCITATION-FUNCTIONS; NI-64;

D O I：

10.1007/s10967-008-7443-9

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Copper-64 was produced by the Ni-64(p, n)Cu-64 reaction using enriched (NiO)-Ni-64 target. We investigated and compared the production yield of Cu-64 for proton beams of various energies by using a thick target. Enriched Ni-64 was recovered with high yield by simple procedures. Imaging studies using positron emission tomography (PET) and positron emitting tracer imaging system (PETIS) were performed. We obtained clear images in PET and PETIS studies. The results of this study indicate that Cu-64 can be utilized as a biomedical tracer for the molecular imaging both in animals and plants.

引用

页码：199 / 205

页数：7

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