Methyl angolensate and mexicanolide-type limonoids from the seeds of Cipadessa baccifera

被引：34

作者：

Siva, Bandi ^{[1
]}

Poornima, B. ^{[1
]}

Venkanna, A. ^{[1
]}

Prasad, K. Rajendra ^{[1
]}

Sridhar, B. ^{[2
]}

Nayak, V. Lakshma ^{[3
]}

Ramakrishna, Sistla ^{[3
]}

Babu, K. Suresh ^{[1
]}

机构：

[1] CSIR, Indian Inst Chem Technol, Div Nat Prod Chem, Hyderabad 500007, Andhra Pradesh, India

[2] CSIR, Indian Inst Chem Technol, Ctr Xray Crystallog, Hyderabad 500007, Andhra Pradesh, India

[3] CSIR, Indian Inst Chem Technol, Div Med Chem & Pharmacol, Hyderabad 500007, Andhra Pradesh, India

来源：

PHYTOCHEMISTRY | 2014年 / 98卷

关键词：

Cipadessa baccifera; Limonoids; Cytotoxic activity; Cancer cell lines; TETRANORTRITERPENOIDS; MANGROVE; LEAVES;

D O I：

10.1016/j.phytochem.2013.11.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Six new methyl angolensate type (1-6) and three new mexicanolide-type (7-9) limonoids, along with six known limonoids (10-15), were isolated from the seeds of Cipadessa baccifera. The structures of all these compounds were established by extensive 1D, 2D NMR, and HRESIMS experiments, and structures of 11 and 13 were further confirmed by a single crystal X-ray diffraction analysis, which are reported for the first time. The cytotoxic activities of these isolates were also studied against A549, MCF7, ME-180, HT-29, B-16, ACHN cancer cell lines using MIT assay, and results indicated that compounds 4,10, and 14 displayed potent cytotoxic activity against B-16, ACHN cell lines with an IC50 values of 8.51 and 7.0 mu g/mL, respectively. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：174 / 182

页数：9

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