Assessing the Susceptibility of Transgenic Mice Overexpressing Deer Prion Protein to Bovine Spongiform Encephalopathy

被引：11

作者：

Vickery, Christopher M. ^{[1
]}

Lockey, Richard ^{[1
]}

Holder, Thomas M. ^{[1
]}

Thorne, Leigh ^{[1
]}

Beck, Katy E. ^{[1
]}

Wilson, Christina ^{[1
]}

Denyer, Margaret ^{[1
]}

Sheehan, John ^{[1
]}

Marsh, Sarah ^{[1
]}

Webb, Paul R. ^{[1
]}

Dexter, Ian ^{[1
]}

Norman, Angela ^{[1
]}

Popescu, Emma ^{[1
]}

Schneider, Amanda ^{[1
]}

Holden, Paul ^{[1
]}

Griffiths, Peter C. ^{[1
]}

Plater, Jane M. ^{[1
]}

Dagleish, Mark P. ^{[2
]}

Martin, Stuart ^{[1
]}

Telling, Glenn C. ^{[3
]}

Simmons, Marion M. ^{[1
]}

Spiropoulos, John ^{[1
]}

机构：

[1] AHVLA Weybridge, Addlestone, Surrey, England

[2] Moredun Res Inst, Penicuik, Midlothian, Scotland

[3] Colorado State Univ, Prion Res Ctr, Dept Microbiol Immunol & Pathol, Ft Collins, CO 80523 USA

来源：

JOURNAL OF VIROLOGY | 2014年 / 88卷 / 03期

关键词：

CHRONIC WASTING DISEASE; QUANTITATIVE TRAIT LOCI; INCUBATION PERIOD; TRANSMISSION; SCRAPIE; SHEEP; ELK; IDENTIFICATION; AEROSOL;

D O I：

10.1128/JVI.02762-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Several transgenic mouse models have been developed which facilitate the transmission of chronic wasting disease (CWD) of cervids and allow prion strain discrimination. The present study was designed to assess the susceptibility of the prototypic mouse line, Tg(CerPrP)1536(+/-), to bovine spongiform encephalopathy (BSE) prions, which have the ability to overcome species barriers. Tg(CerPrP)1536(+/-) mice challenged with red deer-adapted BSE resulted in 90% to 100% attack rates, and BSE from cattle failed to transmit, indicating agent adaptation in the deer.

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收藏

页码：1830 / 1833

页数：4

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