Reductive intramolecular coupling of phthalimides with esters and ketones by low-valent titanium

被引：6

作者：

Kise, Naoki ^{[1
,2
]}

Manto, Tatsuhiro ^{[1
]}

Sakurai, Toshihiko ^{[1
,2
]}

机构：

[1] Tottori Univ, Grad Sch Engn, Dept Chem & Biotechnol, 4-101 Koyama Cho Minami, Tottori 6808552, Japan

[2] Tottori Univ, Ctr Res Green Sustainable Chem, Grad Sch Engn, 4-101 Koyama Cho Minami, Tottori 6808552, Japan

来源：

TETRAHEDRON | 2020年 / 76卷 / 52期

关键词：

Reductive coupling; Low-valent titanium; Phthalimides; Alkylideneisoindlin-1-ones; CYCLIC IMIDES; HYPOLIPIDEMIC ACTIVITY; ALDEHYDES APPLICATION; BIOLOGICAL-ACTIVITY; DERIVATIVES; BENZOPHENONES; CARBONYLATION; CYCLIZATION; LIGANDS; ACCESS;

D O I：

10.1016/j.tet.2020.131725

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reductive intermolecular coupling of phthalimides with esters by low-valent titanium gave five-, six, and seven-membered cyclized products as alpha-hydroxyketones and their further reduced ketones. The obtained cyclized products were transformed to alkylideneisoindolin-1-ones. The reductive intermolecular coupling of phthalimides with ketones by low-valent titanium also gave five-, six-, and seven-membered cyclized products as alkylideneisoindolin-1-ones in one step. (C) 2020 Elsevier Ltd. All rights reserved.

引用

页数：10

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