Genetic Diversity among Staphylococcus aureus Isolates Showing Oxacillin and/or Cefoxitin Resistance Not Linked to the Presence of mec Genes

被引：60

作者：

Argudin, M. Angeles ^{[1
]}

Roisin, S. ^{[1
]}

Nienhaus, L. ^{[1
]}

Dodemont, M. ^{[1
]}

De Mendonca, R. ^{[1
]}

Nonhoff, C. ^{[1
]}

Deplano, A. ^{[1
]}

Denis, O. ^{[1
,2
]}

机构：

[1] Univ Libre Bruxelles, Natl Reference Ctr Staphylococcus Aureus, Dept Microbiol, Hop Erasme, Brussels, Belgium

[2] Univ Libre Bruxelles, Ecole Sante Publ, Brussels, Belgium

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2018年 / 62卷 / 07期

关键词：

beta-lactamase; BORSA; MODSA; PBP; METHICILLIN-RESISTANT; MACROCOCCUS-CASEOLYTICUS; STRAINS; SUSCEPTIBILITY; MUTATIONS; BELGIUM; CEFTAROLINE; BORSA;

D O I：

10.1128/AAC.00091-18

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Methicillin-resistant Staphylococcus aureus isolates lacking mec genes (n = 32), collected from Belgian hospitals, were characterized for their beta-lactamase production and the presence of mutations in pbp genes, the pbp4 promoter, and genes involved in penicillin-binding protein 4 overproduction (gdpP and yjbH). Twelve isolates were beta-lactamase hyperproducers (BHPs), while 12 non-BHP isolates might produce an incomplete GdpP protein. Most isolates showed nucleotide missense mutations in pbp genes. A few isolates also showed mutations in the pbp4 promoter.

引用

页数：6

共 31 条

[1] [Anonymous], 2017, BREAKP TABL INT MICS
[2] Low occurrence of the new species Staphylococcus argenteus in a Staphylococcus aureus collection of human isolates from Belgium
Argudin, M. A.
Dodemont, M.
Vandendriessche, S.
Rottiers, S.
Tribes, C.
Roisin, S.
de Mendonca, R.
Nonhoff, C.
Deplano, A.
Denis, O.
[J]. EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES, 2016, 35 (06) : 1017 - 1022
[3] In vitro activity of ceftaroline against clinical Staphylococcus aureus isolates collected during a national survey conducted in Belgian hospitals
Argudin, M. Angeles
Dodemont, M.
Taguemount, M.
Roisin, S.
de Mendonca, R.
Deplano, A.
Nonhoff, C.
Denis, O.
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2017, 72 (01) : 56 - 59
[4] Novel mutations in penicillin-binding protein genes in clinical Staphylococcus aureus isolates that are methicillin resistant on susceptibility testing, but lack the mec gene
Ba, Xiaoliang
Harrison, Ewan M.
Edwards, Giles F.
Holden, Matthew T. G.
Larsen, Anders Rhod
Petersen, Andreas
Skov, Robert L.
Peacock, Sharon J.
Parkhill, Julian
Paterson, Gavin K.
Holmes, Mark A.
[J]. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2014, 69 (03) : 594 - 597
[5] A mecA-Negative Strain of Methicillin-Resistant Staphylococcus aureus with High-Level β-Lactam Resistance Contains Mutations in Three Genes
Banerjee, Ritu
Gretes, Michael
Harlem, Christopher
Basuino, Li
Chambers, Henry F.
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (11) : 4900 - 4902
[6] Methicillin resistance in Staphylococcus isolates: The "mec alphabet" with specific consideration of mecC, a mec homolog associated with zoonotic S-aureus lineages
Becker, Karsten
Ballhausen, Britta
Koeck, Robin
Kriegeskorte, Andre
[J]. INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 2014, 304 (07) : 794 - 804
[7] Berger-Bachi B., 2009, Staphylococci in human disease, P170, DOI 10.1002/9781444308464.ch8
[8] Ceftobiprole- and Ceftaroline-Resistant Methicillin-Resistant Staphylococcus aureus
Chan, Liana C.
Basuino, Li
Diep, Binh
Hamilton, Stephanie
Chatterjee, Som S.
Chambers, Henry F.
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, 59 (05) : 2960 - 2963
[9] PBP4 Mediates β-Lactam Resistance by Altered Function
Chatterjee, Som S.
Chen, Liang
Gilbert, Aubre
da Costa, Thaina M.
Nair, Vinod
Datta, Sandip K.
Kreiswirth, Barry N.
Chambers, Henry F.
[J]. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2017, 61 (11)
[10] Cross-talk between Two Nucleotide-signaling Pathways in Staphylococcus aureus
Corrigan, Rebecca M.
Bowman, Lisa
Willis, Alexandra R.
Kaever, Volkhard
Gruendling, Angelika
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 290 (09) : 5826 - 5839

← 1 2 3 4 →