Graphene oxide and reduced graphene oxide: Efficient cargo platforms for cancer theranostics

被引：45

作者：

Alemi, Forough ^{[1
,2
,3
]}

Zarezadeh, Reza ^{[1
,2
]}

Sadigh, Aydin Raei ^{[1
,2
]}

Hamishehkar, Hamed ^{[4
]}

Rahimi, Mahdi ^{[5
]}

Majidinia, Maryam ^{[6
]}

Asemi, Zatollah ^{[7
]}

Ebrahimi-Kalan, Abbas ^{[8
]}

Yousefi, Bahman ^{[10
]}

Rashtchizadeh, Nadereh ^{[1
,2
,9
]}

机构：

[1] Tabriz Univ Med Sci, Dept Biochem, Fac Med, Tabriz, Iran

[2] Tabriz Univ Med Sci, Clin Labs, Fac Med, Tabriz, Iran

[3] Tabriz Univ Med Sci, Students Res Comm, Tabriz, Iran

[4] Tabriz Univ Med Sci, Drug Appl Res Ctr, Tabriz, Iran

[5] Lodz Univ Technol, Inst Polymer & Dye Technol, Stefanowskiego 12-16, PL-90924 Lodz, Poland

[6] Urmia Univ Med Sci, Solid Tumor Res Ctr, Orumiyeh, Iran

[7] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Inst Basic Sci, Kashan, Iran

[8] Tabriz Univ Med Sci, Fac Adv Med Sci, Dept Neurosci & Cognit, Tabriz, Iran

[9] Tabriz Univ Med Sci, Connect Tissue Dis Res Ctr, Tabriz, Iran

[10] Tabriz Univ Med Sci, Mol Res Ctr, Tabriz, Iran

来源：

JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY | 2020年 / 60卷

关键词：

Drug delivery; Nanotechnology; Graphene oxide; Neoplasms; TARGETED DRUG-DELIVERY; ANTICANCER DRUG; FOLIC-ACID; IN-VITRO; FLUORESCENT APTASENSOR; MECHANICAL-PROPERTIES; POLYETHYLENE-GLYCOL; PH; REDUCTION; NANOPARTICLES;

D O I：

10.1016/j.jddst.2020.101974

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Drug delivery for successful treatment of cancer, which is potently facilitated by progress in nanotechnology opens new avenue in this field. Graphene oxide (GO) and its derivatives, as the most investigated and used delivery system, have various potential characteristics make it a suitable candidate for cancer treatment. Increased loading capacity, enhanced surface area, capability of reactive oxygen species induction, as well as aptitude for surface functionalization are among the most important features of these nanoparticle. An accumulating body of recent studies have been reported the high efficacy of GO and its derivatives in cancer biosensing, gene delivery, drug delivery, photothermal therapy, combination therapy, and concurrent therapy and diagnostics (theranostics). Therefore, the present review is aimed to elaborate the critical function of GO and its derivatives in cancer diagnosis and therapy.

引用

页数：15