A New Benzofuran Derivative From the Stems of Helicteres hirsuta

被引：7

作者：

Nguyen Thanh Tra ^{[1
]}

Nguyen Thi Thu Ha ^{[1
]}

Ba Thi Cham ^{[1
]}

Le Thi Tu Anh ^{[1
]}

Le Thi Hai Yen ^{[2
]}

Bach Long Giang ^{[3
]}

Dang Thi Tuyet Anh ^{[1
]}

Nguyen Van Tuyen ^{[1
]}

Phan Van Kiem ^{[4
,5
]}

机构：

[1] VAST, Inst Chem, Hanoi, Vietnam

[2] Hanoi Med Coll, Hanoi, Vietnam

[3] Nguyen Tat Thanh Univ, NTT Hitech Insitute, Ho Chi Minh City, Vietnam

[4] VAST, Inst Marine Biochem, 18 Hoang Quoc Viet, Hanoi, Vietnam

[5] Grad Univ Sci & Technol, VAST, Hanoi, Vietnam

来源：

NATURAL PRODUCT COMMUNICATIONS | 2019年 / 14卷 / 06期

关键词：

Helicteres hirsuta; benzofuran derivative; cytotoxic activity; CUCURBITACIN-B; ROOT BARK; CONSTITUENTS; GROWTH; ASSAY;

D O I：

10.1177/1934578X19858814

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new benzofurane 7-methoxy-2-(3-hydroxy-4-methoxyphenyl)-benzofuran-5-carboxylate (1) and 5 known compounds, such as propacin (2), hisbiscolatone A (3), heliclactone (4), rosmarinic acid (5), and syringaldehyde (6), were isolated from methanol extract of the Helicteres hirsuta stems. Their structures were elucidated by spectroscopic analysis as Nuclear Magnetic Resonance (NMR) and Mass Spectroscopy (MS) Furthermore, compounds 1 to 6 were evaluated for their cytotoxic activity against 4 human cancer cell lines such as Lu-1, MCF7, HepG2, and KB. The results showed that compound 2 exhibited moderate cytotoxic activity against Lu-1, MCF7, HepG2, and KB cell lines with IC50 values of 43.97 +/- 2.12, 46.53 +/- 0.75, 52.63 +/- 0.24, and 56.37 +/- 1.04 mu g/mL, respectively. This is the first report of compounds 2 to 6 from H. hirsuta.

引用

页数：5

共 24 条

[1]

Akoury E., 2017, AM RES J CHEM, V2, P17, DOI DOI 10.21694/2577-5898.17003

[2] Coumarins, coumarinolignoids and terpenes from Protium heptaphyllum [J].