An outbreak of necrotizing enterocolitis associated with a novel Clostridium species in a neonatal intensive care unit

被引:56
作者
Alfa, MJ
Robson, D
Davi, M
Bernard, K
Van Caeseele, P
Harding, GKM
机构
[1] St Boniface Gen Hosp, Dept Microbiol, Winnipeg, MB R2H 2A6, Canada
[2] Univ Manitoba, Winnipeg, MB, Canada
[3] Canadian Sci Ctr Human & Anim Hlth, Winnipeg, MB, Canada
关键词
D O I
10.1086/341929
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
An outbreak of necrotizing enterocolitis (NEC) occurred in 6 neonates within a 2-month period. Blood cultures from 3 of these neonates grew the same strain of what appears to be a novel clostridial species for which the name "Clostridium neonatale" has been proposed. A point-prevalence survey that used rectal swabs was performed in our intensive-care and intermediate-care nurseries, and it indicated that 20.8% of neonates carried this same "C. neonatale" strain despite having no evidence of NEC. In conclusion, we describe an outbreak of NEC associated with the novel species, and we suggest that, in larger neonates, carriage of this type of Clostridium species may be a necessary step in the multistage pathogenesis of NEC.
引用
收藏
页码:S101 / S105
页数:5
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