Synthesis of Monofluoromethyl Selenoethers of Aryl and Alkyl from Organoselenocyanate via One-Pot Reaction

被引：23

作者：

Cao, Yuan ^{[1
]}

Jiang, Lvqi ^{[1
]}

Yi, Wenbin ^{[1
]}

机构：

[1] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Jiangsu, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2019年 / 361卷 / 18期

基金：

中国国家自然科学基金;

关键词：

First monofluoromethylselenolation; Aryl; Alkyl; Late-stage monofluoromethylselenolation; CATALYZED TRIFLUOROMETHYLSELENOLATION; ORGANIC SELENOCYANATES; O-DIFLUOROMETHYLATION; FLUORINE; TRIFLUOROMETHYLTHIOLATION; ETHERS; CONVENIENT; PERFLUOROALKYLTHIOLATION; DIFLUOROMETHYLTHIOLATION; THIOETHERS;

D O I：

10.1002/adsc.201900480

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The first practical and feasible approach for the monofluoromethylselenolation of aryl and alkyl halides via one-pot multistep synthesis using KSeCN and ICFH2 is described. Good yields and broad functional group compatibility were obtained. The successful preparation of monofluoromethylselenolated drug-like compounds good practicability of this method. This protocol offered a number of new monofluoromethyl selenoethers, which would accelerate the use of such compounds in the areas of life science.

引用

页码：4360 / 4368

页数：9

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