Uterine serous carcinoma: Molecular features, clinical management, and new and future therapies

被引：27

作者：

Lee, Elizabeth K. ^{[1
]}

Fader, Amanda N. ^{[2
]}

Santin, Alessandro D. ^{[3
]}

Liu, Joyce F. ^{[1
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Div Gynecol Oncol, Boston, MA 02215 USA

[2] Johns Hopkins Sch Med, Dept Gynecol & Obstet, Kelly Gynecol Oncol Serv, Baltimore, MD USA

[3] Yale Univ, Dept Obstet Gynecol & Reprod Sci, Sch Med, New Haven, CT USA

来源：

GYNECOLOGIC ONCOLOGY | 2021年 / 160卷 / 01期

关键词：

CLEAR-CELL CARCINOMA; PHASE-III TRIAL; ENDOMETRIAL CANCER; EARLY-STAGE; IN-VITRO; RADIATION-THERAPY; ADJUVANT CHEMOTHERAPY; GERMLINE MUTATIONS; SINGLE-AGENT; HER2;

D O I：

10.1016/j.ygyno.2020.10.017

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Uterine serous carcinoma (USC) is an aggressive subtype of endometrial cancer. Multimodality treatment with surgery, radiotherapy, and chemotherapy is commonly used, given its propensity for extrauterine spread, distant recurrences, and poor prognosis. However, the use of molecularly-based therapy is expanding. Here, we review key molecular features of USC, discuss current management, and assess the landscape of novel therapies and combinations. (C) 2020 Published by Elsevier Inc.

引用

页码：322 / 332

页数：11

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