pH-independent release of a basic drug from pellets coated with the extended release polymer dispersion Kollicoato® SR 30 D and the enteric polymer dispersion Kollicoato® MAE 30 DP

被引：59
作者：
Dashevsky, A
Kolter, K
Bodmeier, R
机构：
[1] Free Univ Berlin, Coll Pharm, D-12169 Berlin, Germany
[2] BASF AG, Dev Pharma Ingredients, Ludwigshafen, Germany
来源：
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS | 2004年 / 58卷 / 01期
关键词：
enteric polymers; extended release; multiparticulates; pH-independent release; polyvinyl acetate; Kollicoat((R))SR 30 D;
D O I：
10.1016/j.ejpb.2004.03.013
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The objective of this study was to obtain pH-independent release profiles from coated pellets containing drugs with pH-dependent solubility. pH-independent release of the basic model drug verapamil HCl was achieved by coating with a combination of the neutral polymer dispersions Kollicoat(R) SR 30 D (aqueous dispersion of polyvinyl acetate) and the enteric polymer dispersion Kollicoat(R) MAE 30 DP (aqueous dispersion of methacrylic acid and ethyl acrylate copolymer; methacrylic acid copolymer type C). The two polymers where applied either as separate layers (enteric polymer + extended release polymer or vice versa) or as a polymer blend. A careful balance of the ratios of the polymers allowed the achievement of a pH-independent release. Higher amounts of the enteric polymer in the polymer blend resulted in a reversal of the pH-dependency, e.g. a faster release at pH 6.8 than in 0.1 N HCl. (C) 2004 Elsevier B.V. All rights reserved.
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收藏
页码：45 / 49
页数：5
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