Sclerotiorin, from Penicillium frequentans, a potent inhibitor of aldose reductase

被引：27

作者：

Chidananda, C. ^{[1
]}

Rao, L. Jagan Mohan ^{[1
]}

Sattur, A. P. ^{[1
]}

机构：

[1] Cent Food Technol Res Inst, Fermentat Technol & Bioengn Dept, Mysore 570020, Karnataka, India

来源：

BIOTECHNOLOGY LETTERS | 2006年 / 28卷 / 20期

关键词：

aldose reductase; diabetes; Hyperglycemia; inhibitor; Penicillium frequentans; sclerotiorin;

D O I：

10.1007/s10529-006-9133-4

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aldose reductase, the first key enzyme in the polyol pathway, is involved in complications of diabetes. Sclerotiorin, isolated and purified from the fermented broth of Penicillium frequentans, inhibited aldose reductase with an IC50 0.4 mu M. The inhibitor also showed antibacterial activity against Bacillus spp.

引用

页码：1633 / 1636

页数：4

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