PhSeZnCl in the Synthesis of Steroidal -Hydroxy-Phenylselenides Having Antibacterial Activity

被引：13

作者：

Jastrzebska, Izabella ^{[1
]}

Mellea, Stefano ^{[1
]}

Salerno, Valerio ^{[1
]}

Grzes, Pawel Adam ^{[1
]}

Siergiejczyk, Leszek ^{[1
]}

Niemirowicz-Laskowska, Katarzyna ^{[2
]}

Bucki, Robert ^{[2
]}

Monti, Bonifacio ^{[3
]}

Santi, Claudio ^{[3
]}

机构：

[1] Univ Bialystok, Inst Chem, Ul Ciolkowskiego 1K, PL-15245 Bialystok, Poland

[2] Med Univ Bialystok, Dept Microbiol & Nanobiomed Engn, Ul Mickiewicza 2C, PL-15222 Bialystok, Poland

[3] Univ Perugia, Dept Pharmaceut Sci, Grp Catalysis & Organ Green Chem, Via Liceo 1, I-06132 Perugia, Italy

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 09期

关键词：

steroids; selenium; antibacterial; antibiofilm; GLUTATHIONE-S-TRANSFERASE; ANTIOXIDANT; SELENOLATE;

D O I：

10.3390/ijms20092121

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We report here the reaction of in situ prepared PhSeZnCl with steroid derivatives having an epoxide as an electrophilic functionalization. The corresponding ring-opening reaction resulted to be regio- and stereoselective affording to novel phenylselenium-substituted steroids. Assessment of their antibacterial properties against multidrug-resistant bacteria, such as Pseudomonas aeruginosa Xen 5 strain, indicates an interesting bactericidal activity and their ability to prevent bacterial biofilm formation.

引用

页数：13

共 39 条

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