Potentiometric flow injection determination of serum bromide in patients with epilepsy

被引：13
作者：
Katsu, T [1 ]
Mori, Y [1 ]
Matsuka, N [1 ]
Gomita, Y [1 ]
机构：
[1] OKAYAMA UNIV,SCH MED,DEPT HOSP PHARM,OKAYAMA 700,JAPAN
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1997年 / 15卷 / 12期
关键词：
flow injection analysis; ion-selective electrode; bromide; therapeutic drug monitoring; epilepsy;
D O I：
10.1016/S0731-7085(96)02017-1
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
A flow injection system was constructed using a bromide-selective electrode and used to determine serum bromide in patients with epilepsy. A 10-mu l serum sample was injected into a carrier stream flowing at 0.12 mi min(-1). Potential changes and bromide concentrations were linearly related in the range 3-50 mM. The lower limit of detection for serum bromide was 1 mM and this electrode sensitivity spanned the entire concentration range required for bromide therapy (9-24 mM). The results compared favourably with those obtained by colorimetry. (C) 1997 Elsevier Science B.V.
引用
收藏
页码：1829 / 1832
页数：4
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