The 14q restless legs syndrome locus in the French Canadian population

被引：49
作者：
Levchenko, A
Montplaisir, JY
Dubé, MP
Riviere, JB
St-Onge, J
Turecki, G
Xiong, L
Thibodeau, P
Desautels, A
Verlaan, DJ
Rouleau, GA
机构：
[1] McGill Univ, Ctr Hlth, Montreal Gen Hosp, Ctr Res Neurosci,Res Inst, Montreal, PQ H3G 1A4, Canada
[2] Hop Sacre Coeur, Ctr Etud Sommeil & Rythmes Biol, Montreal, PQ H4J 1C5, Canada
[3] Douglas Hosp, Res Ctr, Verdun, PQ H4H 1R3, Canada
来源：
ANNALS OF NEUROLOGY | 2004年 / 55卷 / 06期
关键词：
D O I：
10.1002/ana.20140
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A new restless legs syndrome locus on chromosome 14 recently has been reported in one family of Italian origin. Our study aimed to replicate this finding and determine the importance of this locus in the French Canadian population. Markers spanning the region were genotyped in 14 large families and linkage assessed using two-point and multipoint logarithm of odds scores. Possible linkage to this locus was found in one of our kindreds providing support for the existence of this locus and indicating that this locus may be responsible for a small fraction of French Canadian restless legs syndrome.
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页码：887 / 891
页数：5
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