Chimeric Antigen Receptor T Cells and Hematopoietic Cell Transplantation: How Not to Put the CART Before the Horse

被引：66

作者：

Kenderian, Saad S. ^{[1
,2
]}

Porter, David L. ^{[3
,4
]}

Gill, Saar ^{[1
,3
,4
]}

机构：

[1] Univ Penn, Ctr Cellular Immunotherapies, Philadelphia, PA 19104 USA

[2] Mayo Clin, Dept Med, Div Hematol, Rochester, MN USA

[3] Univ Penn, Sch Med, Div Hematol Oncol, Philadelphia, PA 19104 USA

[4] Univ Penn, Sch Med, Abramson Canc Ctr, Philadelphia, PA 19104 USA

来源：

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION | 2017年 / 23卷 / 02期

关键词：

Chimeric antigen receptor; T cells; CART19; Immunotherapy; Adoptive T cell therapy; Adoptive immunotherapy; Hematopoietic stem cell transplantation; Bone marrow transplantation; ACUTE LYMPHOBLASTIC-LEUKEMIA; ACUTE MYELOID-LEUKEMIA; NON-HODGKIN-LYMPHOMA; B-CELL; ANTITUMOR-ACTIVITY; CYTOKINE RELEASE; ADOPTIVE IMMUNOTHERAPY; THERAPY; EFFICACY; CD8(+);

D O I：

10.1016/j.bbmt.2016.09.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hematopoietic cell transplantation (HCT) remains an important and potentially curative option for most hematologic malignancies. As a form of immunotherapy, allogeneic HCT (allo-HCT) offers the potential for durable remissions but is limited by transplantation- related morbidity and mortality owing to organ toxicity, infection, and graft-versus-host disease. The recent positive outcomes of chimeric antigen receptor T (CART) cell therapy in B cell malignancies may herald a paradigm shift in the management of these disorders and perhaps other hematologic malignancies as well. Clinical trials are now needed to address the relative roles of CART cells and HCT in the context of transplantation-eligible patients. In this review, we summarize the state of the art of the development of CART cell therapy for leukemia, lymphoma, and myeloma and discuss our perspective of how CART cell therapy can be applied in the context of HCT. (C) 2017 American Society for Blood and Marrow Transplantation.

引用

页码：235 / 246

页数：12

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