iPSC for modeling neurodegenerative disorders

被引：24

作者：

Valadez-Barba, Valeria ^{[1
]}

Cota-Coronado, A. ^{[1
,2
]}

Hernandez-Perez, O. R. ^{[1
]}

Lugo-Fabres, Pavel H. ^{[1
]}

Padilla-Camberos, Eduardo ^{[1
]}

Fabian Diaz, Nestor ^{[3
]}

Emmanuel Diaz-Martinez, N. ^{[1
]}

机构：

[1] Ctr Res & Assistance Technol & Design State Jalis, Dept Med & Pharmaceut Biotechnol, Av Normalistas 800, Colinas De Las Normal 44270, Jalisco, Mexico

[2] Univ Melbourne, Florey Inst Neurosci & Mental Hlth, 30 Royal Parade, Parkville, Vic 3052, Australia

[3] Inst Nacl Perinatol Isidro Espinosa Reyes, Dept Fisiol & Desarrollo Celular, Mexico City, DF, Mexico

来源：

REGENERATIVE THERAPY | 2020年 / 15卷

关键词：

iPSCs; Neurodegenerative diseasaes; Alzheimer; Parkinson; PLURIPOTENT STEM-CELLS; ALZHEIMERS-DISEASE; ALPHA-SYNUCLEIN; A-BETA; NEURONS; MOUSE; TRANSPLANTATION; SENSITIVITY; PATHOLOGY; THERAPY;

D O I：

10.1016/j.reth.2020.11.006

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Neurodegenerative disorders such as Parkinson's and Alzheimer's disease, are fundamental health concerns all around the world. The development of novel treatments and new techniques to address these disorders, are being actively studied by researchers and medical personnel. In the present review we will discuss the application of induced Pluripotent Stem Cells (iPSCs) for cell-therapy replacement and disease modelling. The aim of iPSCs is to restore the functionality of the damaged tissue by replacing the impaired cells with competitive ones. To achieve this objective, iPSCs can be properly differentiated into virtually any cell fate and can be strongly translated into human health via in vitro and in vivo disease modeling for the development of new therapies, the discovery of biomarkers for several disorders, the elaboration and testing of new drugs as novel treatments, and as a tool for personalized medicine. (C) 2020, The Japanese Society for Regenerative Medicine. Production and hosting by Elsevier B.V.

引用

页码：332 / 339

页数：8

共 78 条

[11] Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation [J].

Dettmer, Ulf ;

Newman, Andrew J. ;

Soldner, Frank ;

Luth, Eric S. ;

Kim, Nora C. ;

von Saucken, Victoria E. ;

Sanderson, John B. ;

Jaenisch, Rudolf ;

Bartels, Tim ;

Selkoe, Dennis .

NATURE COMMUNICATIONS, 2015, 6

[12] Current Challenges of iPSC-Based Disease Modeling and Therapeutic Implications [J].

Doss, Michael Xavier ;

Sachinidis, Agapios .

CELLS, 2019, 8 (05)

[13] Barriers for Deriving Transgene-Free Pig iPS Cells with Episomal Vectors [J].

Du, Xuguang ;

Feng, Tao ;

Yu, Dawei ;

Wu, Yuanyuan ;

Zou, Huiying ;

Ma, Shuangyu ;

Feng, Chong ;

Huang, Yongye ;

Ouyang, Hongsheng ;

Hu, Xiaoxiang ;

Pan, Dengke ;

Li, Ning ;

Wu, Sen .

STEM CELLS, 2015, 33 (11) :3228-3238

[14] UCHIME improves sensitivity and speed of chimera detection [J].

Edgar, Robert C. ;

Haas, Brian J. ;

Clemente, Jose C. ;

Quince, Christopher ;

Knight, Rob .

BIOINFORMATICS, 2011, 27 (16) :2194-2200

[15]

EDSALL JT, 1995, ADV PROTEIN CHEM, V46, P1, DOI 10.1016/S0065-3233(08)60329-0

[16] FERTILIZATION AND CLEAVAGE IN-VITRO OF PREOVULATOR HUMAN OOCYTES [J].

EDWARDS, RG ;

STEPTOE, PC ;

PURDY, JM .

NATURE, 1970, 227 (5265) :1307-+

[17] Cellular models for Parkinson's disease [J].

Falkenburger, Bjoern H. ;

Saridaki, Theodora ;

Dinter, Elisabeth .

JOURNAL OF NEUROCHEMISTRY, 2016, 139 :121-130

[18] Selective vulnerability in neurodegenerative diseases [J].

Fu, Hongjun ;

Hardy, John ;

Duff, Karen E. .

NATURE NEUROSCIENCE, 2018, 21 (10) :1350-1358

[19] Converging pathways in neurodegeneration, from genetics to mechanisms [J].

Ga, Li ;

Cookson, Mark R. ;

Petrucelli, Leonard ;

La Spade, Albert R. .

NATURE NEUROSCIENCE, 2018, 21 (10) :1300-1309

[20] Cell biology - New potential for human embryonic stem cells [J].

Gearhart, J .

SCIENCE, 1998, 282 (5391) :1061-1062

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