Self-assembling tryptophan-based designer peptides as intracellular delivery vehicles

被引：17
|
作者：
Bhardwaj, Ishanki [1 ]
Jha, Divya [2 ]
Admane, Prasad [2 ]
Panda, Amulya K. [2 ]
Haridas, V. [1 ]
机构：
[1] Indian Inst Technol Delhi, Dept Chem, New Delhi 110016, India
[2] Natl Inst Immunol, Prod Dev Cell, New Delhi 110067, India
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2016年 / 26卷 / 02期
关键词：
Peptide; Self-assembly; Spherical assembly; Tryptophan; Encapsulation; CELL-PENETRATING PEPTIDES; LIPOSOMES; VESICLES; PROTEIN; CARGO; ACID;
D O I：
10.1016/j.bmcl.2015.11.041
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A series of tryptophan-based peptides W1a, b-W4a, b, with diverse architectures were designed and synthesized. These tryptophan containing peptides can self-assemble to spherical particle. This self-assembled system was demonstrated to encapsulate rhodamine B and penetrate the cell membrane. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：672 / 676
页数：5
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