Regioselective 1,4-conjugate hydrocyanation of dienones using potassium hexacyanoferrate(II) as an eco-friendly cyanide source

被引：14

作者：

Li, Zheng ^{[1
]}

Yin, Junjun ^{[1
]}

Li, Tianpeng ^{[1
]}

Wen, Gong ^{[1
]}

Shen, Xiaoli ^{[1
]}

Yang, Jingya ^{[1
]}

机构：

[1] Northwest Normal Univ, Coll Chem & Chem Engn, Lanzhou 730070, Gansu, Peoples R China

来源：

TETRAHEDRON | 2014年 / 70卷 / 35期

基金：

中国国家自然科学基金;

关键词：

Conjugate hydrocyanation; Dienone; Green chemistry; Potassium hexacyanoferrate(II); Regioselectivity; PALLADIUM-CATALYZED CYANATION; ENVIRONMENTALLY BENIGN PROCEDURE; CONJUGATE ADDITION; ARYL HALIDES; ALPHA; BETA-UNSATURATED KETONES; INTRAMOLECULAR ADDITIONS; ASYMMETRIC CYANATION; MICHAEL ADDITION; BENZYL CHLORIDES; MICROWAVE;

D O I：

10.1016/j.tet.2014.06.079

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly regioselective 1,4-conjugate hydrocyanation of dienones using potassium hexacyanoferrate(II) as an original eco-friendly cyanide source, benzoyl chloride as a promoter and potassium carbonate as a catalyst is described. This protocol has advantages of non-toxic cyanating agent, high regioselectivity, high yield, and simple work-up procedure. (C) 2014 Elsevier Ltd. All rights reserved.

引用

页码：5619 / 5625

页数：7

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