Impact of the COVID-19 pandemic on cardiovascular mortality and catherization activity during the lockdown in central Germany: an observational study

被引：60

作者：

Nef, Holger M. ^{[1
,2
]}

Elsaesser, Albrecht ^{[3
]}

Moellmann, Helge ^{[4
]}

Abdel-Hadi, Mohammed ^{[5
]}

Bauer, Timm ^{[6
]}

Brueck, Martin ^{[7
]}

Eggebrecht, Holger ^{[8
]}

Ehrlich, Joachim R. ^{[9
]}

Ferrari, Markus W. ^{[10
]}

Fichtlscherer, Stephan ^{[2
]}

Hink, Ulrich ^{[11
]}

Hoelschermann, Hans ^{[12
]}

Kacapor, Rifat ^{[13
]}

Koeth, Oliver ^{[14
]}

Korboukov, Serguei ^{[15
]}

Lamparter, Steffen ^{[16
]}

Laspoulas, Alexander J. ^{[1
]}

Lehmann, Ralf ^{[17
]}

Liebetrau, Christoph ^{[18
]}

Pluecker, Tobias ^{[19
]}

Pons-Kuehnemann, Joern ^{[20
]}

Schaechinger, Volker ^{[21
]}

Schieffer, Bernhard ^{[22
]}

Schott, Peter ^{[23
]}

Schulze, Matthias ^{[24
]}

Teupe, Claudius ^{[25
]}

Vasa-Nicotera, Mariuca ^{[26
]}

Weber, Michael ^{[27
]}

Weinbrenner, Christoph ^{[28
]}

Werner, Gerald ^{[29
]}

Hamm, Christian W. ^{[1
,18
]}

Doerr, Oliver ^{[1
]}

机构：

[1] Justus Liebig Univ Giessen, Univ Hosp Giessen, Dept Cardiol, Med Clin 1, Klin Str 33, D-35392 Giessen, Germany

[2] Herz Kreislauf Zentrum Klinikum Hersfeld Rotenbur, Dept Cardiol, Rotenburg, Germany

[3] Klinikum Oldenburg, Dept Cardiol, Oldenburg, Germany

[4] St Johannes Hosp, Klin Innere Med 1, Dortmund, Germany

[5] DRK Kliniken Nordhessen, Dept Cardiol, Kassel, Germany

[6] Sana Klinikum Offenbach, Dept Cardiol, Offenbach, Germany

[7] Klinikum Wetzlar, Dept Cardiol, Lahn Dill Kliniken, Wetzlar, Germany

[8] Agaples Frankfurter Diakonie Kliniken, Dept Cardiol, Frankfurt, Germany

[9] St Josefs Hosp Wiesbaden, Dept Cardiol, Wiesbaden, Germany

[10] Helios Dr Horst Schmidt Kliniken, Dept Cardiol, Wiesbaden, Germany

[11] Klinikum Frankfurt Hochst, Dept Cardiol, Frankfurt, Germany

[12] Hochtaunus Kliniken, Dept Cardiol, Bad Homburg, Germany

[13] Kliniken Main Taunus Kreises, Dept Cardiol, Bad Soden Am Taunus, Germany

[14] GPR Gesundheits & Pflegezentrum Russelsheim, Dept Cardiol, Russelsheim, Germany

[15] Hessenklin Stadtkrankenhaus Korbach, Korbach, Germany

[16] Diakonie Krankenhaus Wehrda, Dept Cardiol, Marburg, Germany

[17] Asklepios Kliniken Langen, Dept Cardiol, Langen, Germany

[18] Kerckhoff Heart Ctr, Dept Cardiol, Bad Nauheim, Germany

[19] Eichhof Stiftung Lauterbach, Dept Cardiol, Lauterbach, Germany

[20] Justus Liebig Univ Giessen, Inst Med Informat, Med Stat, Giessen, Germany

[21] Klinikum Fulda, Dept Cardiol, Fulda, Germany

[22] Univ Hosp Marburg, Dept Internal Med Cardiol & Angiol, Marburg, Germany

[23] Klinikum Werra Meissner GmbH, Dept Cardiol, Eschwege, Germany

[24] Asklepios Schwalm Eder Kliniken, Dept Cardiol, Schwalmstadt, Germany

[25] Krankenhaus Sachsenhausen, Dept Cardiol, Frankfurt, Germany

[26] Goethe Univ Frankfurt, Dept Cardiol, Frankfurt, Germany

[27] Kreisklin Gross Umstadt, Dept Cardiol, Gross Umstadt, Germany

[28] Klinikum Hanau, Dept Cardiol, Hanau, Germany

[29] Klinikum Darmstadt, Dept Cardiol, Darmstadt, Germany

来源：

CLINICAL RESEARCH IN CARDIOLOGY | 2021年 / 110卷 / 02期

关键词：

SARS-CoV2; pandemic; COVID-19; Chronic coronary syndrome; Acute coronary syndrome; Cardiovascular mortality;

D O I：

10.1007/s00392-020-01780-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aims During the COVID-19 pandemic, hospital admissions for cardiac care have declined. However, effects on mortality are unclear. Thus, we sought to evaluate the impact of the lockdown period in central Germany on overall and cardiovascular deaths. Simultaneously we looked at catheterization activities in the same region. Methods and results Data from 22 of 24 public health-authorities in central Germany were aggregated during the pandemic related lockdown period and compared to the same time period in 2019. Information on the total number of deaths and causes of death, including cardiovascular mortality, were collected. Additionally, we compared rates of hospitalization (n = 5178) for chronic coronary syndrome (CCS), acute coronary syndrome (ACS), and out of hospital cardiac arrest (OHCA) in 26 hospitals in this area. Data on 5,984 deaths occurring between March 23, 2020 and April 26, 2020 were evaluated. In comparison to the reference non-pandemic period in 2019 (deaths: n = 5832), there was a non-significant increase in all-cause mortality of 2.6% [incidence rate ratio (IRR) 1.03, 95% confidence interval (CI) 0.99-1.06; p = 0.16]. Cardiovascular and cardiac mortality increased significantly by 7.6% (IRR 1.08, 95%-CI 1.01-1.14; p = 0.02) and by 11.8% (IRR 1.12, 95%-CI 1.05-1.19; p < 0.001), respectively. During the same period, our data revealed a drop in cardiac catherization procedures. Conclusion During the COVID-19-related lockdown a significant increase in cardiovascular mortality was observed in central Germany, whereas catherization activities were reduced. The mechanisms underlying both of these observations should be investigated further in order to better understand the effects of a pandemic-related lockdown and social-distancing restrictions on cardiovascular care and mortality. [GRAPHICS] .

引用

页码：292 / 301

页数：10

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