Adsorption of Paracetamol and Acetylsalicylic Acid onto Commercial Activated Carbons

被引：18

作者：

Beninati, Sabina ^{[1
]}

Semeraro, Domenica ^{[1
]}

Mastragostino, Marina ^{[1
]}

机构：

[1] Univ Bologna, Fac Pharm, Dept Met Sci Electrochem & Chem Tech, I-40127 Bologna, Italy

来源：

ADSORPTION SCIENCE & TECHNOLOGY | 2008年 / 26卷 / 09期

关键词：

D O I：

10.1260/026361708788251349

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The adsorption of paracetamol (PAR) and acetylsalicylic acid (ASA) onto high-surface-area, commercial activated carbons was investigated at 26 degrees C via adsorption isotherms at different pH values, including pH 1.5 to simulate conditions existing in the stomach. A wide-ranging characterization of the carbons, including analysis of their morphology and surface chemistry, was undertaken, with the actual surface areas of the carbons available for PAR and ASA adsorption being estimated by taking the molecular sizes of the drugs into account. This provided an understanding of the differences in the drug adsorption behaviour of the carbons.

引用

页码：721 / 734

页数：14

共 26 条

[11] Activated Charcoal Revisited
Gaudreault, Pierre
[J]. CLINICAL PEDIATRIC EMERGENCY MEDICINE, 2005, 6 (02) : 76 - 80
[12] Effect of ethanol and pH on the adsorption of acetaminophen (paracetamol) to high surface activated charcoal, in vitro studies
Hoegberg, LCG
Angelo, HR
Christophersen, AB
Christensen, HR
[J]. JOURNAL OF TOXICOLOGY-CLINICAL TOXICOLOGY, 2002, 40 (01): : 59 - 67
[13] Jepsen F., 2005, CURRENT PAEDIAT, V15, P563, DOI DOI 10.1016/J.CUPE.2005.08.006
[14] Poisoning
Jones, Lewis O.
[J]. ANAESTHESIA AND INTENSIVE CARE MEDICINE, 2006, 7 (04) : 132 - 134
[15] The effect of protein binding on ibuprofen adsorption to activated carbons
Melillo, M
Phillips, GJ
Davies, JG
Lloyd, AW
Tennison, SR
Kozynchenko, OP
Mikhalovsky, SV
[J]. CARBON, 2004, 42 (03) : 565 - 571
[16] Activated carbons for the adsorption of ibuprofen
Mestre, A. S.
Pires, J.
Nogueira, J. M. F.
Carvalho, A. P.
[J]. CARBON, 2007, 45 (10) : 1979 - 1988
[17] Adsorption of organic molecules from aqueous solutions on carbon materials
Moreno-Castilla, C
[J]. CARBON, 2004, 42 (01) : 83 - 94
[18] The formation of carbon surface oxygen complexes by oxygen and ozone. The effect of transition metal oxides
Mul, G
Neeft, JPA
Kapteijn, F
Moulijn, JA
[J]. CARBON, 1998, 36 (09) : 1269 - 1276
[19] GRANULAR ACTIVATED CARBON - IMPORTANCE OF SURFACE-PROPERTIES IN THE ADSORPTION OF NATURALLY-OCCURRING ORGANICS
NEWCOMBE, G
HAYES, R
DRIKAS, M
[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS, 1993, 78 : 65 - 71
[20] Adsorption of salicylic acid onto polymeric adsorbents and activated charcoal
Otero, M
Grande, CA
Rodrigues, AE
[J]. REACTIVE & FUNCTIONAL POLYMERS, 2004, 60 : 203 - 213

← 1 2 3 →