Impact of puberty on the evolution of cerebral perfusion during adolescence

被引：164

作者：

Satterthwaite, Theodore D. ^{[1
,2
]}

Shinohara, Russell T. ^{[2
,3
]}

Wolf, Daniel H. ^{[1
,2
]}

Hopson, Ryan D. ^{[1
]}

Elliott, Mark A. ^{[2
,4
]}

Vandekar, Simon N. ^{[1
]}

Ruparel, Kosha ^{[1
]}

Calkins, Monica E. ^{[1
]}

Roalf, David R. ^{[1
]}

Gennatas, Efstathios D. ^{[1
]}

Jackson, Chad ^{[1
]}

Erus, Guray ^{[2
]}

Prabhakaran, Karthik ^{[1
]}

Davatzikos, Christos ^{[2
]}

Detre, John A. ^{[5
]}

Hakonarson, Hakon ^{[6
]}

Gur, Ruben C. ^{[1
,2
,7
]}

Gur, Raquel E. ^{[1
,2
]}

机构：

[1] Univ Penn, Dept Psychiat, Brain & Behav Lab, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Radiol, Ctr Biomed Image Comp & Analyt, Philadelphia, PA 19104 USA

[3] Univ Penn, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA

[4] Univ Penn, Dept Radiol, Ctr Magnet Resonance & Opt Imaging, Philadelphia, PA 19104 USA

[5] Univ Penn, Dept Neurol, Ctr Funct Neuroimaging, Philadelphia, PA 19104 USA

[6] Childrens Hosp Philadelphia, Ctr Appl Genom, Philadelphia, PA 19104 USA

[7] Philadelphia Vet Adm Med Ctr, Philadelphia, PA 19104 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2014年 / 111卷 / 23期

关键词：

BRAINS DEFAULT NETWORK; MEDIAL TEMPORAL-LOBE; NITROUS-OXIDE METHOD; BLOOD-FLOW; SEX-DIFFERENCES; DEVELOPMENTAL TRAJECTORIES; FUNCTIONAL CONNECTIVITY; AEROBIC GLYCOLYSIS; GENDER-DIFFERENCES; HEALTHY-CHILDREN;

D O I：

10.1073/pnas.1400178111

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Puberty is the defining biological process of adolescent development, yet its effects on fundamental properties of brain physiology such as cerebral blood flow (CBF) have never been investigated. Capitalizing on a sample of 922 youths ages 8-22 y imaged using arterial spin labeled MRI as part of the Philadelphia Neurodevelopmental Cohort, we studied normative developmental differences in cerebral perfusion in males and females, as well as specific associations between puberty and CBF. Males and females had conspicuously divergent nonlinear trajectories in CBF evolution with development as modeled by penalized splines. Seventeen brain regions, including hubs of the executive and default mode networks, showed a robust nonlinear age-by-sex interaction that surpassed Bonferroni correction. Notably, within these regions the decline in CBF was similar between males and females in early puberty and only diverged in midpuberty, with CBF actually increasing in females. Taken together, these results delineate sex-specific growth curves for CBF during youth and for the first time to our knowledge link such differential patterns of development to the effects of puberty.

引用

页码：8643 / 8648

页数：6

共 80 条

[41] Age and sex differences in cerebral hemodynamics - A transcranial Doppler study [J].

Matteis, M ;

Troisi, E ;

Monaldo, BC ;

Caltagirone, C ;

Silvestrini, M .

STROKE, 1998, 29 (05) :963-967

[42] VALIDATION OF A SELF-ADMINISTERED INSTRUMENT TO ASSESS STAGE OF ADOLESCENT DEVELOPMENT [J].

MORRIS, NM ;

UDRY, JR .

JOURNAL OF YOUTH AND ADOLESCENCE, 1980, 9 (03) :271-280

[43] GONADAL-STEROIDS INFLUENCE AXON SPROUTING IN THE HIPPOCAMPAL DENTATE GYRUS - A SEXUALLY DIMORPHIC RESPONSE [J].

MORSE, JK ;

SCHEFF, SW ;

DEKOSKY, ST .

EXPERIMENTAL NEUROLOGY, 1986, 94 (03) :649-658

[44] Sex Differences and the Impact of Steroid Hormones on the Developing Human Brain [J].

Neufang, Susanne ;

Specht, Karsten ;

Hausmann, Markus ;

Guentuerkuen, Onur ;

Herpertz-Dahlmann, Beate ;

Fink, Gereon R. ;

Konrad, Kerstin .

CEREBRAL CORTEX, 2009, 19 (02) :464-473

[45] Cerebral blood flow is increased during controlled ovarian stimulation [J].

Nevo, Ori ;

Soustiel, Jean F. ;

Thaler, Israel .

AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2007, 293 (06) :H3265-H3269

[46] THE EMERGENCE OF GENDER DIFFERENCES IN DEPRESSION DURING ADOLESCENCE [J].

NOLENHOEKSEMA, S ;

GIRGUS, JS .

PSYCHOLOGICAL BULLETIN, 1994, 115 (03) :424-443

[47]

Ogawa A, 1987, No To Shinkei, V39, P113

[48] OPINION Why do many psychiatric disorders emerge during adolescence? [J].

Paus, Tomas ;

Keshavan, Matcheri ;

Giedd, Jay N. .

NATURE REVIEWS NEUROSCIENCE, 2008, 9 (12) :947-957

[49] SEX STEROIDS AND BRAIN STRUCTURE IN PUBERTAL BOYS AND GIRLS: A MINI-REVIEW OF NEUROIMAGING STUDIES [J].

Peper, J. S. ;

Pol, H. E. Hulshoff ;

Crone, E. A. ;

van Honk, J. .

NEUROSCIENCE, 2011, 191 :28-37

[50] Sex steroids and connectivity in the human brain: A review of neuroimaging studies [J].

Peper, Jiska S. ;

van den Heuvel, Martijn P. ;

Mandl, Rene C. W. ;

Pol, Hilleke E. Hulshoff ;

van Honk, Jack .

PSYCHONEUROENDOCRINOLOGY, 2011, 36 (08) :1101-1113

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