Epidemiology of tsutsugamushi disease and its relationship with meteorological factors in Xiamen city, China

Tsutsugamushi disease (TD) is an acute infectious disease caused byOrientia tsutsugamushi. This study aimed to analyze the epidemiological features of TD, investigate chigger mites and their hosts, and investigate the meteorological factors affecting TD incidence and the host ofO.tsutsugamushiin Xiamen city, China. Data on reported TD cases were collected from 2006 to 2018. Spearman's correlation test were used for identifying the relationship between meteorological factors and TD incidence and whether meteorological factors affect the host ofO.tsutsugamushi. The incidence of reported TD increased gradually from 2006, reached a peak of 4.59 per 100,000 persons in 2014, and then decreased gradually. The TD incidence was seasonal, with epidemic periods occurred mainly in summer and autumn. Patients aged 40-60 years had the highest proportion of cases, accounting for 44.44% of the total cases. Farmers had the largest number of cases among all occupational groups.Rattus Norvegicuswas the most common host, accounting for the largest proportion of cases (73.00%), and the highest rat density was observed in March and October every year. There were significant positive correlations between the number of reported cases and average temperature, sunshine duration, and rainfall as well as between rat density and average temperature. On phylogenetic analysis, 7 sequences of hosts and human TD cases obtained from health records demonstrated the highest similarities to the Kato, Karp, and Gilliam strains. No correlations were observed between rat density, and sunshine duration and rainfall. The transmission of TD in Xiamen city, China, was seasonal, and its incidence was affected by several meteorological factors including average temperature, sunshine duration, and rainfall. However, the host ofO.tsutsugamushiwas only affected by average temperature. Author summary Tsutsugamushi disease (TD) is a natural focal disease caused byOrientia tsutsugamushi, which is widespread in some areas. The incidence of TD is greatly influenced by meteorological factors. Therefore, it is essential to analyze the epidemiological features of TD, investigate chigger mites and their hosts, and explore the relationship between meteorological factors and TD incidence and whether meteorological factors affect the host ofO.tsutsugamushiin Xiamen city, China. The results showed significant positive correlations between the number of reported cases and average temperature, sunshine duration, and rainfall. A positive correlation between rat density and average temperature. No correlations were observed between the rat density and sunshine duration and rainfall. We believe our findings may provide scientific basis for studies or health strategies conducted in areas that are meteorologically similar in characteristics with Xiamen city, China.