Risk factors for opportunistic infections in infliximab-treated patients: the importance of screening in prevention

被引：80

作者：

Garcia-Vidal, C. ^{[1
,2
]}

Rodriguez-Fernandez, S. ^{[2
]}

Teijon, S. ^{[2
]}

Esteve, M. ^{[3
]}

Rodriguez-Carballeira, M. ^{[2
]}

Lacasa, J. M. ^{[2
]}

Salvador, G. ^{[4
]}

Garau, J. ^{[2
]}

机构：

[1] Hosp Univ Bellvitge, Infect Dis Serv, Barcelona 08907, Spain

[2] Univ Barcelona, Hosp Mutua Terrassa, Serv Internal Med, Barcelona, Spain

[3] Univ Barcelona, Hosp Mutua Terrassa, Serv Gastroenterol, Barcelona, Spain

[4] Univ Barcelona, Hosp Mutua Terrassa, Serv Rheumatol, Barcelona, Spain

来源：

EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES | 2009年 / 28卷 / 04期

关键词：

TUBERCULIN SKIN-TEST; NECROSIS-FACTOR ANTAGONISTS; FACTOR-ALPHA ANTAGONISTS; GAMMA RELEASE ASSAYS; RHEUMATOID-ARTHRITIS; LATENT TUBERCULOSIS; HEPATITIS-B; THERAPY; METHOTREXATE; REACTIVATION;

D O I：

10.1007/s10096-008-0628-x

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We sought to determine factors associated with opportunistic infections (OI) in infliximab-treated patients. A retrospective study cohort (1999-2004) was examined. Nine OI were diagnosed in 94 infliximab-treated patients: tuberculosis (four), visceral leishmaniasis (one), pyogenic muscular abscess (one Salmonella spp. and one Streptococcus pneumoniae), and two viral infections (hepatitis B virus [HBV] and zoster ophthalmicus). The risk for OI was significantly higher in the first year of treatment (odds ratio [OR] 8; 95% confidence interval [CI] 2-50). Previous treatment with more than two immunosuppressive drugs was the only factor related to OI (OR 8.686; 95% CI 1.889-39.943). We identified the subset of patients treated with infliximab who had a higher risk for OI. The screening of latent infections is key to diminishing the incidence of these infections.

引用

页码：331 / 337

页数：7

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