Presence of Thrombin-Activatable Fibrinolysis Inhibitor in Helicobacter pylori-Associated Gastroduodenal Disease

被引：2

作者：

Ikeda, Ayumi ^{[2
]}

Gabazza, Esteban C. ^{[1
]}

Morser, John ^{[1
]}

Imoto, Ichiro ^{[2
]}

Kuroda, Mikihito ^{[2
]}

D'Alessandro-Gabazza, Corina N. ^{[4
]}

Hara, Kenichiro

Ruiz, Daniel Boveda ^{[1
]}

Bernabe, Paloma Gil ^{[2
]}

Katsurahara, Masaki ^{[2
]}

Toda, Masaaki ^{[1
]}

Kobayashi, Yoshinao ^{[2
]}

Yano, Yutaka ^{[3
]}

Sumida, Yasuhiro ^{[3
]}

Suzuki, Koji ^{[5
]}

Taguchi, Osamu ^{[4
]}

Takei, Yoshiyuki ^{[2
]}

机构：

[1] Mie Univ, Dept Immunol, Grad Sch Med, Tsu, Mie 5148507, Japan

[2] Mie Univ, Dept Gastroenterol & Hepatol, Grad Sch Med, Tsu, Mie 5148507, Japan

[3] Mie Univ, Dept Diabet & Endocrinol & Diabet, Grad Sch Med, Tsu, Mie 5148507, Japan

[4] Mie Univ, Dept Pulm & Crit Care Med, Grad Sch Med, Tsu, Mie 5148507, Japan

[5] Mie Univ, Dept Mol Pathobiol, Grad Sch Med, Tsu, Mie 5148507, Japan

来源：

HELICOBACTER | 2009年 / 14卷 / 02期

关键词：

coagulation; gastritis; ulcer; fibrinolysis; infection; GASTRIC-MUCOSA; CARBOXYPEPTIDASE-R; INFECTION; PATHOGENESIS; COAGULATION; DEPOSITION; RECEPTORS; PERITONITIS; EXPRESSION; MECHANISM;

D O I：

10.1111/j.1523-5378.2009.00662.x

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Thrombin-activatable fibrinolysis inhibitor (TAFI) plays a role in the regulation of coagulation and inflammation. In addition to inhibiting the fibrinolytic system, TAFI may also regulate the bradykinin and complement systems. We hypothesized that TAFI also plays a role in defense mechanisms of the gastric mucosa during Helicobacter pylori infection. This study comprised 65 patients with gastroduodenal disorders: 41 patients with H. pylori infection, 13 without, and 11 patients with cured H. pylori infection. The gastric intramucosal concentrations of TAFI were measured by enzyme immunoassay. The gastric levels of TAFI and plasminogen activator inhibitor-1 were significantly increased in patients with H. pylori compared to those without infection or cured H. pylori. The presence of TAFI was detected in gastric mucosal epithelial cells. The concentration of TAFI was correlated with the degree of gastric mucosal atrophy, inflammation, and disease activity. These results show that TAFI is present in the gastric mucosa and that it may play a role in the pathogenesis of H. pylori infection-associated gastroduodenal disorders.

引用

页码：147 / 155

页数：9

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