Convenient, two-step synthesis of 2-styrylquinolines: an application of the CAN-catalyzed vinylogous type-II Povarov reaction

被引：36

作者：

Sridharan, Vellaisamy ^{[1
]}

Avendano, Carmen ^{[1
]}

Menendez, J. Carlos ^{[1
]}

机构：

[1] Univ Complutense, Fac Farm, Dept Quim Organ & Farmaceut, E-28040 Madrid, Spain

来源：

TETRAHEDRON | 2009年 / 65卷 / 10期

关键词：

CERIUM(IV) AMMONIUM-NITRATE; DIELS-ALDER REACTIONS; DOUBLE NUCLEOPHILIC-ADDITION; COIL BLOCK-COPOLYMERS; ONE-POT SYNTHESIS; INTEGRASE INHIBITORS; ACRIDONE ALKALOIDS; HIV-1; INTEGRASE; FACILE SYNTHESIS; STYRYLQUINOLINE DERIVATIVES;

D O I：

10.1016/j.tet.2008.12.077

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new, experimentally simple, synthesis of 2-styrylquinolines was developed using a two-step sequence based on a CAN-catalyzed three-component type-II vinylogous Povarov reaction from arylamines, cinnamaldehydes, and electron-rich cyclic and noncyclic vinyl ethers. The tetrahydroquinolines thus obtained were subsequently aromatized to styrylquinolines by DDQ-promoted dehydrogenation. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：2087 / 2096

页数：10

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