Effect of Wasabi Extract on Inflammatory Response of BV2 Cells Induced by Lipopolysaccharide<bold> </bold>

被引：5

作者：

Chen, Chen ^{[1
]}

Qiu Yuanyuan ^{[1
]}

机构：

[1] Nantong Univ, Sch Elect Informat Jiangsu, Nantong 226019, Peoples R China

来源：

2018 INTERNATIONAL SEMINAR ON FOOD SAFETY AND ENVIRONMENTAL ENGINEERING (FSEE 2018) | 2019年 / 78卷

关键词：

D O I：

10.1051/e3sconf/20197801011

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Objective: This study was to investigate the effect of wasabi extract 6-(methylsulfinyl)hexyl isothiocyanate (6-MITC) on preventing neuroinflammation. Methods: The activation of BV2 microglia cell was introduced by LPS to establish an in vitro neuroinflammatory cell model, and the influence of 6-MITC on the survival rate of BV2 cells was deceted by MTT assay and the mRNA expression level of inflammatory factors in each group were deceted by RT-qPCR. Results: 6-MITC can significantly down-regulate mRNA expression levels of the inflammatory factor interleukin-1 beta, IL-6, tumor necrosis factor-alpha (TNF-alpha) and nitric oxide synthase (iNOS) after activation of BV2 cells induced by LPS. Conclusion: 6-MITC can inhibit LPS-induced microglia activation and decrease inflammatory response of BV2 cells.<bold> </bold>

引用

页数：4

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