Anti-Inflammatory and Gastroprotective Effects of Escin

被引：14

作者：

Yang, Yunqi ^{[1
]}

Wang, Linlin ^{[1
]}

Yuan, Man ^{[1
]}

Yu, Qi ^{[1
]}

Fu, Fenghua ^{[1
]}

机构：

[1] Univ Yantai, Sch Pharm, Dept Pharmacol, Yantai 264000, Peoples R China

来源：

NATURAL PRODUCT COMMUNICATIONS | 2020年 / 15卷 / 12期

基金：

中国国家自然科学基金;

关键词：

escin; triterpenoid; anti-inflammatory; gastrointestinal protection; mechanisms; Aesculus hippocastanum; CHRONIC VENOUS INSUFFICIENCY; AESCULUS-HIPPOCASTANUM L; FACTOR-KAPPA-B; HORSE-CHESTNUT; GASTROINTESTINAL TRANSIT; OXIDATIVE STRESS; POSSIBLE INVOLVEMENT; POSTOPERATIVE ILEUS; SODIUM AESCINATE; BETA-AESCIN;

D O I：

10.1177/1934578X20982111

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Escin is a triterpenoid saponin extracted from the fruit of Aesculus wilsonii Rehd. and Aesculus hippocastanum (Hippocastanaceae). Clinically, it is widely used in the treatment of edema induced by either trauma or surgery, as well as treating chronic venous insufficiency. The anti-inflammatory and antiedema effects of escin have been extensively investigated. This article systematically reviews the effects of escin on inflammation and gastrointestinal diseases, including its role in inflammation, as an antioxidant, and in inhibiting gastric acid secretion and promoting gastrointestinal movement, especially, the molecular mechanism. The advantages and potential uses of escin have also been discussed.

引用

页数：10

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