Anti-Inflammatory and Gastroprotective Effects of Escin

被引:14
作者
Yang, Yunqi [1 ]
Wang, Linlin [1 ]
Yuan, Man [1 ]
Yu, Qi [1 ]
Fu, Fenghua [1 ]
机构
[1] Univ Yantai, Sch Pharm, Dept Pharmacol, Yantai 264000, Peoples R China
基金
中国国家自然科学基金;
关键词
escin; triterpenoid; anti-inflammatory; gastrointestinal protection; mechanisms; Aesculus hippocastanum; CHRONIC VENOUS INSUFFICIENCY; AESCULUS-HIPPOCASTANUM L; FACTOR-KAPPA-B; HORSE-CHESTNUT; GASTROINTESTINAL TRANSIT; OXIDATIVE STRESS; POSSIBLE INVOLVEMENT; POSTOPERATIVE ILEUS; SODIUM AESCINATE; BETA-AESCIN;
D O I
10.1177/1934578X20982111
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Escin is a triterpenoid saponin extracted from the fruit of Aesculus wilsonii Rehd. and Aesculus hippocastanum (Hippocastanaceae). Clinically, it is widely used in the treatment of edema induced by either trauma or surgery, as well as treating chronic venous insufficiency. The anti-inflammatory and antiedema effects of escin have been extensively investigated. This article systematically reviews the effects of escin on inflammation and gastrointestinal diseases, including its role in inflammation, as an antioxidant, and in inhibiting gastric acid secretion and promoting gastrointestinal movement, especially, the molecular mechanism. The advantages and potential uses of escin have also been discussed.
引用
收藏
页数:10
相关论文
共 73 条
[1]   Emerging understandings of 2019-nCoV [J].
不详 .
LANCET, 2020, 395 (10221) :311-311
[2]   Effect of aescine on hypoxia-induced neutrophil adherence to umbilical vein endothelium [J].
Bougelet, C ;
Roland, IH ;
Ninane, N ;
Arnould, T ;
Remacle, J ;
Michiels, C .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1998, 345 (01) :89-95
[3]   PROPOSALS FOR THE CLASSIFICATION AND NOMENCLATURE OF FUNCTIONAL RECEPTORS FOR 5-HYDROXYTRYPTAMINE [J].
BRADLEY, PB ;
ENGEL, G ;
FENIUK, W ;
FOZARD, JR ;
HUMPHREY, PPA ;
MIDDLEMISS, DN ;
MYLECHARANE, EJ ;
RICHARDSON, BP ;
SAXENA, PR .
NEUROPHARMACOLOGY, 1986, 25 (06) :563-576
[4]   STUDY OF THE CONTRACTILE EFFECT OF 5-HYDROXYTRYPTAMINE (5-HT) IN THE ISOLATED LONGITUDINAL MUSCLE STRIP FROM GUINEA-PIG ILEUM - EVIDENCE FOR 2 DISTINCT RELEASE MECHANISMS [J].
BUCHHEIT, KH ;
ENGEL, G ;
MUTSCHLER, E ;
RICHARDSON, B .
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1985, 329 (01) :36-41
[5]   Escin attenuates oxidative damage, apoptosis and lipid peroxidation in a model of cyclophosphamide-induced liver damage [J].
Cengiz, Mustafa ;
Kutlu, Hatice Mehtap ;
Peker Cengiz, Betul ;
Ayhanci, Adnan .
DRUG AND CHEMICAL TOXICOLOGY, 2022, 45 (03) :1180-1187
[6]   Determination of four major saponins in the seeds of Aesculus chinensis Bunge using accelerated solvent extraction followed by high-performance liquid chromatography and electrospray-time of flight mass spectrometry [J].
Chen, Junhui ;
Li, Wenlong ;
Yang, Baijuan ;
Guo, Xiuchun ;
Lee, Frank Sen-Chun ;
Wang, Xiaoru .
ANALYTICA CHIMICA ACTA, 2007, 596 (02) :273-280
[7]   Aescin reduces oxidative stress and provides neuroprotection in experimental traumatic spinal cord injury [J].
Cheng, Peng ;
Kuang, Fang ;
Ju, Gong .
FREE RADICAL BIOLOGY AND MEDICINE, 2016, 99 :405-417
[8]   Gastrointestinal Manifestations of Autoimmune Diseases Requiring Critical Care [J].
Collins-Yoder, Angela .
CRITICAL CARE NURSING CLINICS OF NORTH AMERICA, 2018, 30 (01) :1-12
[9]  
Cui Y, 2019, EUR REV MED PHARMACO, V23, P5923, DOI 10.26355/eurrev_201907_18337
[10]   Combined treatment with low dose prednisone and escin improves the anti-arthritic effect in experimental arthritis [J].
Du, Yuan ;
Song, Yanqin ;
Zhang, Leiming ;
Zhang, Menglin ;
Fu, Fenghua .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2016, 31 :257-265