ERS/EAACI statement on severe exacerbations in asthma in adults: facts, priorities and key research questions

被引：74

作者：

Bourdin, Arnaud ^{[1
]}

Bjermer, Leif ^{[2
]}

Brightling, Christopher ^{[3
]}

Brusselle, Guy G. ^{[4
]}

Chanez, Pascal ^{[5
]}

Chung, Kian Fan ^{[6
]}

Custovic, Adnan ^{[7
]}

Diamant, Zuzana ^{[8
,9
]}

Diver, Sarah ^{[10
]}

Djukanovic, Ratko ^{[11
]}

Hamerlijnck, Dominique

Horvath, Ildiko ^{[12
,13
]}

Johnston, Sebastian L. ^{[14
]}

Kanniess, Frank

Papadopoulos, Nikos ^{[15
,16
]}

Papi, Alberto ^{[17
]}

Russell, Richard J. ^{[18
]}

Ryan, Dermot ^{[19
,20
]}

Samitas, Konstantinos ^{[21
,22
]}

Tonia, Thomy ^{[23
]}

Zervas, Eleftherios ^{[24
]}

Gaga, Mina ^{[24
]}

机构：

[1] Univ Montpellier, CHU Montpellier, PhyMedExp, INSERM,CNRS, Montpellier, France

[2] Dept Resp Med & Allergy, Lung & Allergy Res Unit, Lund, Sweden

[3] Univ Leicester, NIHR BRC Resp Med, Inst Lung Hlth, Dept Infect Immun & Inflammat, Leicester, Leics, England

[4] Ghent Univ Hosp, Dept Resp Dis, Ghent, Belgium

[5] Univ Marseille, Marseille, France

[6] Imperial Coll, Natl Heart & Lung Inst, London, England

[7] Imperial Coll London, Dept Paediat, London, England

[8] Skane Univ Hosp, Dept Resp Med & Allergol, Lund, Sweden

[9] QPS Netherlands, Resp & Allergy Res, Groningen, Netherlands

[10] Glenfield Hosp, Resp Biomed Res Unit, Coll Life Sci, Dept Resp Sci, Leicester, Leics, England

[11] Univ Hosp Southampton NHS Fdn Trust, Southampton, Hants, England

[12] Semmelweis Univ, Natl Koranyi Inst Pulmonol, Budapest, Hungary

[13] Semmelweis Univ, Dept Publ Hlth, Budapest, Hungary

[14] Imperial Coll London, Dept Resp Med, London, England

[15] Univ Manchester, Div Infect Immun & Resp Med, Manchester, Lancs, England

[16] Univ Athens, Pediat Clin 2, Allergy Dept, Athens, Greece

[17] Univ Ferrara, Resp Med, Ferrara, Italy

[18] Univ Leicester, Dept Infect Immun & Inflammat, NIHR Leicester Biomed Res Ctr, Inst Lung Hlth, Leicester, Leics, England

[19] Univ Edinburgh, Ctr Populat Hlth Sci, Allergy & Resp Res Grp, Edinburgh, Midlothian, Scotland

[20] Woodbrook Med Ctr, Loughborough, Leics, England

[21] Athens Chest Hosp, Resp Med Dept 7, Athens, Greece

[22] Athens Chest Hosp, Asthma Ctr, Athens, Greece

[23] Univ Bern, Inst Social & Prevent Med, Bern, Switzerland

[24] Athens Chest Hosp, Resp Med Dept 7, Athens, Greece

来源：

EUROPEAN RESPIRATORY JOURNAL | 2019年 / 54卷 / 03期

关键词：

NEAR-FATAL ASTHMA; SEVERE EOSINOPHILIC ASTHMA; EXHALED NITRIC-OXIDE; MODIFIABLE RISK-FACTORS; DOSE INHALED CORTICOSTEROIDS; INTERMITTENT BETA-AGONISTS; GENOME-WIDE ASSOCIATION; QUALITY-OF-LIFE; DOUBLE-BLIND; BUDESONIDE-FORMOTEROL;

D O I：

10.1183/13993003.00900-2019

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Despite the use of effective medications to control asthma, severe exacerbations in asthma are still a major health risk and require urgent action on the part of the patient and physician to prevent serious outcomes such as hospitalisation or death. Moreover, severe exacerbations are associated with substantial healthcare costs and psychological burden, including anxiety and fear for patients and their families. The European Academy of Allergy and Clinical Immunology (EAACI) and the European Respiratory Society (ERS) set up a task force to search for a clear definition of severe exacerbations, and to also define research questions and priorities. The statement includes comments from patients who were members of the task force.

引用

页数：25

共 220 条

[1] Effectiveness of voriconazole in the treatment of Aspergillus fumigatus-associated asthma (EVITA3 study) [J].